Gene description for PLCB1
Gene name phospholipase C, beta 1 (phosphoinositide-specific)
Gene symbol PLCB1
Other names/aliases -
Species Bos taurus
 Database cross references - PLCB1
ExoCarta ExoCarta_287026
Entrez Gene 287026
UniProt P10894  
 PLCB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PLCB1
Molecular Function
    calmodulin binding GO:0005516 IEA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IEA
    GTPase activator activity GO:0005096 IEA
    lamin binding GO:0005521 IEA
    enzyme binding GO:0019899 IEA
    phosphatidylinositol phospholipase C activity GO:0004435 IMP
    signal transducer activity GO:0004871 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    interleukin-12-mediated signaling pathway GO:0035722 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    interleukin-1-mediated signaling pathway GO:0070498 IEA
    positive regulation of embryonic development GO:0040019 IEA
    memory GO:0007613 IEA
    lipid catabolic process GO:0016042 IEA
    activation of meiosis involved in egg activation GO:0060466 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    positive regulation of acrosome reaction GO:2000344 IEA
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 IEA
    negative regulation of monocyte extravasation GO:2000438 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IEA
    fat cell differentiation GO:0045444 IEA
    positive regulation of GTPase activity GO:0043547 IEA
    interleukin-15-mediated signaling pathway GO:0035723 IEA
    intracellular signal transduction GO:0035556 IEA
    regulation of fertilization GO:0080154 IEA
    positive regulation of CD24 biosynthetic process GO:2000560 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    positive regulation of JNK cascade GO:0046330 IEA
    G-protein coupled acetylcholine receptor signaling pathway GO:0007213 IEA
    positive regulation of myoblast differentiation GO:0045663 IEA
    positive regulation of interleukin-12 production GO:0032735 IEA
    cerebral cortex development GO:0021987 IEA
    glutamate receptor signaling pathway GO:0007215 IEA
    positive regulation of developmental growth GO:0048639 IEA
Subcellular Localization
    nuclear chromatin GO:0000790 IEA
    nuclear membrane GO:0031965 IEA
    cytoplasm GO:0005737 ISS
    nuclear speck GO:0016607 IEA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PLCB1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLCB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3R1 9368
Reconstituted Complex Homo sapiens
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