Gene description for Dcn
Gene name decorin
Gene symbol Dcn
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Dcn
ExoCarta ExoCarta_29139
Vesiclepedia VP_29139
Entrez Gene 29139
UniProt Q01129  
 Dcn identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Dcn
Molecular Function
    collagen binding GO:0005518 IDA
    glycosaminoglycan binding GO:0005539 IEA
    glycosaminoglycan binding GO:0005539 ISO
    extracellular matrix binding GO:0050840 IEA
    extracellular matrix binding GO:0050840 ISO
Biological Process
    kidney development GO:0001822 IEP
    placenta development GO:0001890 IEP
    skeletal muscle tissue development GO:0007519 IEP
    response to mechanical stimulus GO:0009612 IEP
    positive regulation of autophagy GO:0010508 ISO
    negative regulation of endothelial cell migration GO:0010596 IEA
    negative regulation of endothelial cell migration GO:0010596 ISO
    positive regulation of macroautophagy GO:0016239 IEA
    positive regulation of macroautophagy GO:0016239 ISO
    negative regulation of angiogenesis GO:0016525 IEA
    negative regulation of angiogenesis GO:0016525 ISO
    response to lipopolysaccharide GO:0032496 IEP
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    positive regulation of mitochondrial depolarization GO:0051901 IEA
    positive regulation of mitochondrial depolarization GO:0051901 ISO
    positive regulation of mitochondrial fission GO:0090141 IEA
    positive regulation of mitochondrial fission GO:0090141 ISO
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IEA
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    collagen type VI trimer GO:0005589 IDA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified Dcn in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Dcn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Gja1  
Affinity Capture-MS Rattus norvegicus
3 Otub1 293705
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
4 Ubc  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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