Gene description for Capn2
Gene name calpain 2, (m/II) large subunit
Gene symbol Capn2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Capn2
ExoCarta ExoCarta_29154
Entrez Gene 29154
UniProt Q07009  
 Capn2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Capn2
Molecular Function
    protein heterodimerization activity GO:0046982 IPI
    cytoskeletal protein binding GO:0008092 IDA
    calcium ion binding GO:0005509 IDA
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 ISO
    peptidase activity GO:0008233 ISO
    protein binding GO:0005515 IPI
Biological Process
    response to hypoxia GO:0001666 IEP
    proteolysis GO:0006508 TAS
    protein autoprocessing GO:0016540 IDA
    myoblast fusion GO:0007520 ISO
    regulation of cytoskeleton organization GO:0051493 IEA
    blastocyst development GO:0001824 ISO
    cellular response to amino acid stimulus GO:0071230 ISO
Subcellular Localization
    dendrite GO:0030425 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 TAS
    chromatin GO:0000785 ISO
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    pseudopodium GO:0031143 ISO
    membrane raft GO:0045121 ISS
    cytosol GO:0005829 ISS
    Golgi apparatus GO:0005794 ISO
    perinuclear endoplasmic reticulum GO:0097038 ISO
    endoplasmic reticulum GO:0005783 ISO
    lysosome GO:0005764 ISO
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified Capn2 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Capn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Capn2 is involved
No pathways found





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