Gene description for GRM7
Gene name glutamate receptor, metabotropic 7
Gene symbol GRM7
Other names/aliases GLUR7
Species Homo sapiens
 Database cross references - GRM7
ExoCarta ExoCarta_2917
Entrez Gene 2917
HGNC 4599
MIM 604101
UniProt Q14831  
 GRM7 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GRM7
Molecular Function
    serine binding GO:0070905 IDA
    glutamate binding GO:0016595 IDA
    calcium ion binding GO:0005509 IDA
    PDZ domain binding GO:0030165 NAS
    group III metabotropic glutamate receptor activity GO:0001642 IDA
    voltage-gated calcium channel activity GO:0005245 IEA
    adenylate cyclase inhibitor activity GO:0010855 IDA
    glutamate receptor activity GO:0008066 IDA
    calcium channel regulator activity GO:0005246 IBA
Biological Process
    sensory perception of sound GO:0007605 IMP
    adult behavior GO:0030534 IEA
    negative regulation of cAMP biosynthetic process GO:0030818 IDA
    regulation of synaptic transmission, glutamatergic GO:0051966 IBA
    negative regulation of adenylate cyclase activity GO:0007194 IDA
    behavioral fear response GO:0001662 IMP
    negative regulation of glutamate secretion GO:0014050 ISS
    conditioned taste aversion GO:0001661 IEA
    short-term memory GO:0007614 IEA
    transmission of nerve impulse GO:0019226 IEA
    sensory perception of smell GO:0007608 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 IDA
    synaptic transmission GO:0007268 IDA
    regulation of cyclase activity GO:0031279 IDA
Subcellular Localization
    dendritic shaft GO:0043198 ISS
    integral component of plasma membrane GO:0005887 NAS
    postsynaptic membrane GO:0045211 ISS
    dendrite GO:0030425 IDA
    receptor complex GO:0043235 IDA
    presynaptic membrane GO:0042734 IBA
    axon GO:0030424 ISS
    plasma membrane GO:0005886 TAS
    asymmetric synapse GO:0032279 ISS
    integral component of membrane GO:0016021 IDA
    cell cortex GO:0005938 IDA
    presynaptic active zone GO:0048786 ISS
 Experiment description of studies that identified GRM7 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GRM7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKCA 5578
Affinity Capture-Western Homo sapiens
2 GNAQ 2776
Reconstituted Complex Homo sapiens
3 CALM1 801
Invivo Homo sapiens
Invitro Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which GRM7 is involved
Class C/3 (Metabotropic glutamate/pheromone receptors) TAS Reactome
G alpha (i) signalling events TAS Reactome

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