Gene description for Psen1
Gene name	presenilin 1
Gene symbol	Psen1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Psen1
ExoCarta	ExoCarta_29192
Entrez Gene	29192
UniProt	P97887
Psen1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Psen1

Molecular Function     endopeptidase activity GO:0004175 ISO     beta-catenin binding GO:0008013 ISO     PDZ domain binding GO:0030165 ISO     calcium channel activity GO:0005262 ISO     aspartic-type endopeptidase activity GO:0004190 IEA     peptidase activity GO:0008233 IDA     cadherin binding GO:0045296 ISO     protein binding GO:0005515 IPI Biological Process     post-embryonic development GO:0009791 ISO     skeletal system morphogenesis GO:0048705 ISO     choline transport GO:0015871 ISO     calcium ion transmembrane transport GO:0070588 ISO     cellular protein metabolic process GO:0044267 ISO     cellular calcium ion homeostasis GO:0006874 ISO     single organismal cell-cell adhesion GO:0016337 ISO     protein transport GO:0015031 ISO     thymus development GO:0048538 ISO     cerebral cortex cell migration GO:0021795 ISO     brain development GO:0007420 ISO     beta-amyloid metabolic process GO:0050435 ISO     locomotion GO:0040011 ISO     Notch receptor processing GO:0007220 ISO     negative regulation of axonogenesis GO:0050771 ISO     memory GO:0007613 ISO     regulation of phosphorylation GO:0042325 ISO     hematopoietic progenitor cell differentiation GO:0002244 ISO     positive regulation of coagulation GO:0050820 ISO     forebrain development GO:0030900 ISO     endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO     smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 ISO     intracellular signal transduction GO:0035556 IEA     activation of MAPKK activity GO:0000186 ISO     embryonic limb morphogenesis GO:0030326 ISO     protein glycosylation GO:0006486 ISO     T cell receptor signaling pathway GO:0050852 ISO     dorsal/ventral neural tube patterning GO:0021904 ISO     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO     Notch signaling pathway GO:0007219 ISO     negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000059 ISO     brain morphogenesis GO:0048854 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     myeloid leukocyte differentiation GO:0002573 ISO     neural retina development GO:0003407 IEP     positive regulation of catalytic activity GO:0043085 ISS     autophagy GO:0006914 ISO     neuron apoptotic process GO:0051402 ISO     segmentation GO:0035282 ISO     neurogenesis GO:0022008 ISO     neuron differentiation GO:0030182 ISO     epithelial cell proliferation GO:0050673 ISO     regulation of protein binding GO:0043393 ISO     neuron migration GO:0001764 ISO     membrane protein ectodomain proteolysis GO:0006509 ISS     positive regulation of transcription, DNA-templated GO:0045893 ISO     canonical Wnt signaling pathway GO:0060070 IBA     negative regulation of neuron apoptotic process GO:0043524 IMP     amyloid precursor protein catabolic process GO:0042987 ISO     synaptic vesicle targeting GO:0016080 ISO     negative regulation of ubiquitin-protein transferase activity GO:0051444 ISO     heart looping GO:0001947 ISO     autophagosome assembly GO:0000045 ISO     learning or memory GO:0007611 ISO     regulation of resting membrane potential GO:0060075 ISO     negative regulation of protein phosphorylation GO:0001933 ISO     positive regulation of dendritic spine development GO:0060999 ISO     negative regulation of apoptotic signaling pathway GO:2001234 ISO     heart development GO:0007507 ISO     positive regulation of apoptotic process GO:0043065 ISO     regulation of synaptic transmission, glutamatergic GO:0051966 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     beta-amyloid formation GO:0034205 ISO     cerebral cortex development GO:0021987 ISO     positive regulation of receptor recycling GO:0001921 ISO     neuron development GO:0048666 ISO     cellular response to DNA damage stimulus GO:0006974 ISO     regulation of synaptic plasticity GO:0048167 ISO     blood vessel development GO:0001568 ISO     somitogenesis GO:0001756 ISO     Cajal-Retzius cell differentiation GO:0021870 ISO     cell fate specification GO:0001708 ISO     myeloid dendritic cell differentiation GO:0043011 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     regulation of epidermal growth factor-activated receptor activity GO:0007176 ISO     calcium ion transport GO:0006816 IBA     positive regulation of protein kinase activity GO:0045860 ISO     negative regulation of protein kinase activity GO:0006469 ISO     L-glutamate transport GO:0015813 ISO     mitochondrial transport GO:0006839 ISO     eye photoreceptor cell development GO:0042462 NAS     protein maturation GO:0051604 ISO     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of epidermal growth factor-activated receptor activity GO:0007175 ISO     skin morphogenesis GO:0043589 ISO     response to oxidative stress GO:0006979 ISO     proteolysis GO:0006508 ISO     T cell activation involved in immune response GO:0002286 ISO     protein processing GO:0016485 ISS Subcellular Localization     centrosome GO:0005813 ISO     nuclear membrane GO:0031965 ISO     nucleus GO:0005634 ISO     protein complex GO:0043234 IDA     dendrite GO:0030425 ISO     membrane raft GO:0045121 ISO     endoplasmic reticulum GO:0005783 ISS     smooth endoplasmic reticulum GO:0005790 ISO     cell GO:0005623 ISO     nuclear outer membrane GO:0005640 ISO     growth cone GO:0030426 ISO     Golgi apparatus GO:0005794 ISS     ciliary rootlet GO:0035253 ISO     mitochondrion GO:0005739 ISS     membrane GO:0016020 ISO     perinuclear region of cytoplasm GO:0048471 IBA     mitochondrial inner membrane GO:0005743 IDA     membrane-bounded organelle GO:0043227 ISO     cell cortex GO:0005938 IBA     axon GO:0030424 ISO     gamma-secretase complex GO:0070765 ISO     cell surface GO:0009986 IDA     Z disc GO:0030018 IBA     intracellular GO:0005622 ISO     endoplasmic reticulum membrane GO:0005789 IEA     aggresome GO:0016235 ISS     plasma membrane GO:0005886 ISS     cytoplasmic vesicle GO:0031410 ISO     integral component of plasma membrane GO:0005887 ISS     apical plasma membrane GO:0016324 IBA     neuron projection GO:0043005 IDA     kinetochore GO:0000776 ISO     neuronal cell body GO:0043025 ISO     dendritic shaft GO:0043198 ISO     lysosomal membrane GO:0005765 IDA     neuromuscular junction GO:0031594 IDA     Golgi membrane GO:0000139 IEA     rough endoplasmic reticulum GO:0005791 ISO