Gene description for Psen1
Gene name	presenilin 1
Gene symbol	Psen1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Psen1
ExoCarta	ExoCarta_29192
Vesiclepedia	VP_29192
Entrez Gene	29192
UniProt	P97887
Psen1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Psen1

Molecular Function     endopeptidase activity GO:0004175 IDA     endopeptidase activity GO:0004175 ISO     aspartic-type endopeptidase activity GO:0004190 ISO     calcium channel activity GO:0005262 ISO     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 ISO     peptidase activity GO:0008233 IDA     PDZ domain binding GO:0030165 ISO     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IBA     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISO     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISO     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISS     cadherin binding GO:0045296 ISO     ATPase binding GO:0051117 ISO     growth factor receptor binding GO:0070851 ISO Biological Process     autophagosome assembly GO:0000045 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     blood vessel development GO:0001568 ISO     cell fate specification GO:0001708 ISO     somitogenesis GO:0001756 ISO     neuron migration GO:0001764 ISO     positive regulation of receptor recycling GO:0001921 ISO     negative regulation of protein phosphorylation GO:0001933 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     heart looping GO:0001947 ISO     positive regulation of L-glutamate import across plasma membrane GO:0002038 ISO     hematopoietic progenitor cell differentiation GO:0002244 ISO     astrocyte activation involved in immune response GO:0002265 ISO     T cell activation involved in immune response GO:0002286 ISO     myeloid leukocyte differentiation GO:0002573 ISO     neural retina development GO:0003407 IEP     negative regulation of protein kinase activity GO:0006469 ISO     protein glycosylation GO:0006486 ISO     membrane protein ectodomain proteolysis GO:0006509 IBA     membrane protein ectodomain proteolysis GO:0006509 IMP     membrane protein ectodomain proteolysis GO:0006509 ISO     membrane protein ectodomain proteolysis GO:0006509 ISS     mitochondrial transport GO:0006839 ISO     intracellular calcium ion homeostasis GO:0006874 ISO     autophagy GO:0006914 ISO     DNA damage response GO:0006974 ISO     DNA damage response GO:0006974 ISO     response to oxidative stress GO:0006979 ISO     negative regulation of epidermal growth factor-activated receptor activity GO:0007175 ISO     regulation of epidermal growth factor-activated receptor activity GO:0007176 ISO     Notch signaling pathway GO:0007219 IBA     Notch signaling pathway GO:0007219 ISO     Notch receptor processing GO:0007220 ISO     Notch receptor processing GO:0007220 ISO     brain development GO:0007420 ISO     heart development GO:0007507 ISO     learning or memory GO:0007611 ISO     learning or memory GO:0007611 ISO     memory GO:0007613 ISO     memory GO:0007613 ISO     post-embryonic development GO:0009791 ISO     gene expression GO:0010467 ISO     regulation of gene expression GO:0010468 ISO     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 ISO     regulation of neuron projection development GO:0010975 ISO     regulation of neuron projection development GO:0010975 ISS     protein transport GO:0015031 ISO     choline transport GO:0015871 ISO     synaptic vesicle targeting GO:0016080 ISO     protein processing GO:0016485 IBA     protein processing GO:0016485 IDA     protein processing GO:0016485 ISO     protein processing GO:0016485 ISO     protein processing GO:0016485 ISS     cerebellum development GO:0021549 IEP     cerebral cortex cell migration GO:0021795 ISO     Cajal-Retzius cell differentiation GO:0021870 ISO     dorsal/ventral neural tube patterning GO:0021904 ISO     cerebral cortex development GO:0021987 ISO     neurogenesis GO:0022008 ISO     neuron differentiation GO:0030182 ISO     embryonic limb morphogenesis GO:0030326 ISO     forebrain development GO:0030900 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO     endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO     endoplasmic reticulum calcium ion homeostasis GO:0032469 ISS     positive regulation of tumor necrosis factor production GO:0032760 ISO     amyloid-beta formation GO:0034205 IBA     amyloid-beta formation GO:0034205 ISO     amyloid-beta formation GO:0034205 ISO     amyloid-beta formation GO:0034205 ISS     segmentation GO:0035282 ISO     intracellular signal transduction GO:0035556 IEA     locomotion GO:0040011 ISO     positive regulation of protein import into nucleus GO:0042307 ISO     regulation of phosphorylation GO:0042325 ISO     eye photoreceptor cell development GO:0042462 NAS     amyloid precursor protein metabolic process GO:0042982 ISO     amyloid precursor protein metabolic process GO:0042982 ISS     amyloid precursor protein catabolic process GO:0042987 ISO     amyloid precursor protein catabolic process GO:0042987 ISO     myeloid dendritic cell differentiation GO:0043011 ISO     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     negative regulation of neuron apoptotic process GO:0043524 IMP     skin morphogenesis GO:0043589 ISO     positive regulation of glycolytic process GO:0045821 ISO     positive regulation of protein kinase activity GO:0045860 ISO     positive regulation of DNA-templated transcription GO:0045893 ISO     astrocyte activation GO:0048143 ISO     regulation of synaptic plasticity GO:0048167 ISO     thymus development GO:0048538 ISO     neuron development GO:0048666 ISO     neuron development GO:0048666 ISO     skeletal system morphogenesis GO:0048705 ISO     brain morphogenesis GO:0048854 ISO     amyloid-beta metabolic process GO:0050435 ISO     epithelial cell proliferation GO:0050673 ISO     negative regulation of axonogenesis GO:0050771 ISO     synapse organization GO:0050808 ISO     positive regulation of coagulation GO:0050820 ISO     T cell receptor signaling pathway GO:0050852 ISO     sequestering of calcium ion GO:0051208 ISO     neuron apoptotic process GO:0051402 ISO     negative regulation of ubiquitin-protein transferase activity GO:0051444 ISO     smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 ISO     protein maturation GO:0051604 ISO     regulation of synaptic transmission, glutamatergic GO:0051966 ISO     calcium ion homeostasis GO:0055074 IBA     regulation of resting membrane potential GO:0060075 ISO     regulation of canonical Wnt signaling pathway GO:0060828 ISO     regulation of canonical Wnt signaling pathway GO:0060828 ISS     positive regulation of dendritic spine development GO:0060999 ISO     neuron cellular homeostasis GO:0070050 ISO     calcium ion transmembrane transport GO:0070588 IEA     apoptotic signaling pathway GO:0097190 ISO     cell-cell adhesion GO:0098609 ISO     regulation of synaptic vesicle cycle GO:0098693 ISO     L-glutamate import across plasma membrane GO:0098712 ISO     regulation of postsynapse organization GO:0099175 ISO     protein catabolic process at postsynapse GO:0140249 ISO     cellular response to amyloid-beta GO:1904646 ISO     positive regulation of amyloid fibril formation GO:1905908 ISO     neuron projection maintenance GO:1990535 ISO     negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 ISO     negative regulation of apoptotic signaling pathway GO:2001234 ISO Subcellular Localization     Golgi membrane GO:0000139 IEA     kinetochore GO:0000776 ISO     nucleus GO:0005634 ISO     nuclear outer membrane GO:0005640 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     mitochondrial inner membrane GO:0005743 IDA     lysosomal membrane GO:0005765 IDA     early endosome GO:0005769 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     endoplasmic reticulum membrane GO:0005789 IEA     smooth endoplasmic reticulum GO:0005790 ISO     rough endoplasmic reticulum GO:0005791 ISO     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISS     centrosome GO:0005813 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell cortex GO:0005938 ISO     synaptic vesicle GO:0008021 IDA     cell surface GO:0009986 IDA     membrane GO:0016020 ISO     membrane GO:0016020 ISS     aggresome GO:0016235 ISO     aggresome GO:0016235 ISS     cell junction GO:0030054 ISO     axon GO:0030424 ISO     dendrite GO:0030425 ISO     dendrite GO:0030425 ISO     growth cone GO:0030426 ISO     growth cone GO:0030426 ISS     cytoplasmic vesicle GO:0031410 ISO     neuromuscular junction GO:0031594 IDA     early endosome membrane GO:0031901 IEA     nuclear membrane GO:0031965 ISO     protein-containing complex GO:0032991 IDA     protein-containing complex GO:0032991 ISO     ciliary rootlet GO:0035253 ISO     sarcolemma GO:0042383 IDA     presynaptic membrane GO:0042734 IDA     neuron projection GO:0043005 ISO     neuronal cell body GO:0043025 ISO     dendritic shaft GO:0043198 ISO     membrane raft GO:0045121 ISO     gamma-secretase complex GO:0070765 IBA     gamma-secretase complex GO:0070765 ISO     gamma-secretase complex GO:0070765 ISS     synaptic membrane GO:0097060 IDA     postsynapse GO:0098794 IEA     glutamatergic synapse GO:0098978 ISO