Gene description for Erlin2
Gene name ER lipid raft associated 2
Gene symbol Erlin2
Other names/aliases RGD1309010
Spfh2
Species Rattus norvegicus
 Database cross references - Erlin2
ExoCarta ExoCarta_290823
Vesiclepedia VP_290823
Entrez Gene 290823
UniProt B5DEH2  
 Erlin2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Erlin2
Molecular Function
    cholesterol binding GO:0015485 IBA
    ubiquitin protein ligase binding GO:0031625 ISO
Biological Process
    cholesterol metabolic process GO:0008203 IEA
    SREBP signaling pathway GO:0032933 IBA
    SREBP signaling pathway GO:0032933 ISO
    ERAD pathway GO:0036503 ISO
    regulation of cholesterol biosynthetic process GO:0045540 ISO
    negative regulation of cholesterol biosynthetic process GO:0045541 ISO
    negative regulation of fatty acid biosynthetic process GO:0045717 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    protein-containing complex GO:0032991 ISO
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Erlin2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Erlin2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Aph1a  
Affinity Capture-Western Rattus norvegicus
2 Ncstn 289231
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
3 Psenen 292788
Affinity Capture-Western Rattus norvegicus
4 Itpr1  
Affinity Capture-Western Rattus norvegicus
5 Erlin1  
Affinity Capture-Western Rattus norvegicus
6 Dao  
Affinity Capture-MS Rattus norvegicus
7 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
8 Psen1 29192
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Erlin2 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport IEA Reactome
Transport of small molecules IEA Reactome





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