Gene description for Psenen
Gene name presenilin enhancer gamma secretase subunit
Gene symbol Psenen
Other names/aliases RGD1312037
Species Rattus norvegicus
 Database cross references - Psenen
ExoCarta ExoCarta_292788
Entrez Gene 292788
UniProt Q6QI68  
 Psenen identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Psenen
Biological Process
    positive regulation of catalytic activity GO:0043085 ISO
    Notch receptor processing GO:0007220 ISO
    protein processing GO:0016485 ISO
    membrane protein ectodomain proteolysis GO:0006509 ISO
    Notch signaling pathway GO:0007219 IEA
Subcellular Localization
    gamma-secretase complex GO:0070765 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 ISO
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 ISO
    integral component of plasma membrane GO:0005887 ISO
 Experiment description of studies that identified Psenen in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Psenen
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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