Gene description for Gria3
Gene name glutamate receptor, ionotropic, AMPA 3
Gene symbol Gria3
Other names/aliases GLUR3
GluA3
GluR-3
GluR-C
GluR-K3
Species Rattus norvegicus
 Database cross references - Gria3
ExoCarta ExoCarta_29628
Vesiclepedia VP_29628
Entrez Gene 29628
UniProt P19492  
 Gria3 identified in sEVs derived from the following tissue/cell type
Cortical neurones 16446100    
 Gene ontology annotations for Gria3
Molecular Function
    amyloid-beta binding GO:0001540 IPI
    glutamate-gated receptor activity GO:0004970 IDA
    glutamate-gated receptor activity GO:0004970 ISO
    AMPA glutamate receptor activity GO:0004971 IBA
    AMPA glutamate receptor activity GO:0004971 IDA
    AMPA glutamate receptor activity GO:0004971 IEA
    AMPA glutamate receptor activity GO:0004971 ISO
    protein binding GO:0005515 IPI
    ligand-gated monoatomic ion channel activity GO:0015276 IEA
    glutamate-gated calcium ion channel activity GO:0022849 IDA
    signaling receptor activity GO:0038023 IEA
    ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 IEA
    ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 ISO
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IBA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IEA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 ISO
Biological Process
    regulation of receptor recycling GO:0001919 IMP
    response to lithium ion GO:0010226 IEP
    calcium-mediated signaling GO:0019722 IEA
    monoatomic ion transmembrane transport GO:0034220 IEA
    ionotropic glutamate receptor signaling pathway GO:0035235 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    modulation of chemical synaptic transmission GO:0050804 IBA
    protein homotetramerization GO:0051289 IEA
    protein homotetramerization GO:0051289 ISO
    protein homotetramerization GO:0051289 ISS
    protein heterotetramerization GO:0051290 IEA
    protein heterotetramerization GO:0051290 ISO
    protein heterotetramerization GO:0051290 ISS
    regulation of postsynaptic membrane potential GO:0060078 IEA
    long-term synaptic potentiation GO:0060291 IEA
    long-term synaptic potentiation GO:0060291 ISO
    long-term synaptic potentiation GO:0060291 ISS
    response to fungicide GO:0060992 IEP
    regulation of presynaptic membrane potential GO:0099505 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    ionotropic glutamate receptor complex GO:0008328 TAS
    postsynaptic density GO:0014069 IDA
    membrane GO:0016020 ISO
    dendrite GO:0030425 IDA
    asymmetric synapse GO:0032279 IDA
    AMPA glutamate receptor complex GO:0032281 IBA
    AMPA glutamate receptor complex GO:0032281 IDA
    AMPA glutamate receptor complex GO:0032281 IEA
    AMPA glutamate receptor complex GO:0032281 ISO
    protein-containing complex GO:0032991 IPI
    presynaptic membrane GO:0042734 IDA
    neuronal cell body GO:0043025 IDA
    synaptic cleft GO:0043083 IDA
    terminal bouton GO:0043195 IDA
    dendritic spine GO:0043197 IBA
    dendritic spine GO:0043197 IDA
    dendritic shaft GO:0043198 IDA
    perikaryon GO:0043204 IDA
    postsynaptic membrane GO:0045211 IDA
    postsynaptic membrane GO:0045211 IDA
    postsynaptic membrane GO:0045211 IEA
    postsynaptic membrane GO:0045211 ISO
    presynaptic active zone membrane GO:0048787 IDA
    parallel fiber to Purkinje cell synapse GO:0098688 IEA
    parallel fiber to Purkinje cell synapse GO:0098688 ISO
    postsynaptic density membrane GO:0098839 IBA
    postsynaptic density membrane GO:0098839 IDA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Gria3 in sEVs
1
Experiment ID 30
MISEV standards
EM
Biophysical techniques
Alix|TSG101|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors "Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R"
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gria3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gria1  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
2 Gria2 29627
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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