Gene description for Gria3
Gene name glutamate receptor, ionotropic, AMPA 3
Gene symbol Gria3
Other names/aliases GLUR3
GluA3
GluR-3
GluR-C
GluR-K3
Species Rattus norvegicus
 Database cross references - Gria3
ExoCarta ExoCarta_29628
Entrez Gene 29628
UniProt P19492  
 Gria3 identified in exosomes derived from the following tissue/cell type
Cortical neurones 16446100    
 Gene ontology annotations for Gria3
Molecular Function
    PDZ domain binding GO:0030165 IPI
    alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:0004971 ISO
    ionotropic glutamate receptor activity GO:0004970 IEA
    extracellular-glutamate-gated ion channel activity GO:0005234 IEA
    protein binding GO:0005515 IPI
Biological Process
    ionotropic glutamate receptor signaling pathway GO:0035235 ISO
    regulation of receptor recycling GO:0001919 IMP
    response to fungicide GO:0060992 IEP
    ion transmembrane transport GO:0034220 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    response to lithium ion GO:0010226 IEP
Subcellular Localization
    asymmetric synapse GO:0032279 IDA
    perikaryon GO:0043204 IDA
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0032281 ISO
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IBA
    synaptic cleft GO:0043083 IDA
    postsynaptic membrane GO:0045211 ISO
    protein complex GO:0043234 IPI
    membrane GO:0016020 ISO
    postsynaptic density GO:0014069 IDA
    cell junction GO:0030054 IEA
    neuronal cell body GO:0043025 IDA
    dendrite GO:0030425 IDA
    ionotropic glutamate receptor complex GO:0008328 TAS
    dendritic shaft GO:0043198 IDA
    dendritic spine GO:0043197 IDA
    terminal bouton GO:0043195 IDA
 Experiment description of studies that identified Gria3 in exosomes
1
Experiment ID 30
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gria3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gria3 is involved
No pathways found





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