Gene description for Gria2
Gene name glutamate receptor, ionotropic, AMPA 2
Gene symbol Gria2
Other names/aliases GluA2
GluR-K2
GluR2
gluR-B
Species Rattus norvegicus
 Database cross references - Gria2
ExoCarta ExoCarta_29627
Entrez Gene 29627
UniProt P19491  
 Gria2 identified in exosomes derived from the following tissue/cell type
Cortical neurones 16446100    
 Gene ontology annotations for Gria2
Molecular Function
    PDZ domain binding GO:0030165 IPI
    identical protein binding GO:0042802 IPI
    extracellular-glutamate-gated ion channel activity GO:0005234 ISO
    ionotropic glutamate receptor activity GO:0004970 TAS
    protein binding GO:0005515 IPI
    alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:0004971 TAS
    receptor activity GO:0004872 IDA
    calcium channel regulator activity GO:0005246 TAS
    protein kinase binding GO:0019901 IPI
    kainate selective glutamate receptor activity GO:0015277 IDA
Biological Process
    protein tetramerization GO:0051262 IDA
    ionotropic glutamate receptor signaling pathway GO:0035235 ISS
    synaptic transmission GO:0007268 ISO
    synaptic transmission, glutamatergic GO:0035249 IBA
    response to fungicide GO:0060992 IEP
    regulation of receptor recycling GO:0001919 IMP
    response to lithium ion GO:0010226 IEP
    receptor internalization GO:0031623 IDA
    positive regulation of synaptic transmission GO:0050806 IMP
    ion transmembrane transport GO:0034220 IEA
    regulation of synaptic transmission, glutamatergic GO:0051966 IMP
    establishment of protein localization GO:0045184 IMP
Subcellular Localization
    neuronal cell body GO:0043025 IDA
    ionotropic glutamate receptor complex GO:0008328 TAS
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    neuron projection GO:0043005 ISO
    dendrite GO:0030425 IDA
    membrane GO:0016020 ISO
    dendritic shaft GO:0043198 IDA
    growth cone GO:0030426 IDA
    cell junction GO:0030054 IEA
    protein complex GO:0043234 IPI
    synaptic membrane GO:0097060 ISO
    terminal bouton GO:0043195 IDA
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0032281 ISO
    presynaptic membrane GO:0042734 IDA
    plasma membrane GO:0005886 IBA
    integral component of plasma membrane GO:0005887 IDA
    dendritic spine GO:0043197 IDA
    cell surface GO:0009986 IDA
    asymmetric synapse GO:0032279 IDA
    synaptic vesicle membrane GO:0030672 IDA
    postsynaptic membrane GO:0045211 ISO
    postsynaptic density GO:0014069 IDA
    endoplasmic reticulum GO:0005783 ISO
    synapse GO:0045202 ISO
    synaptic vesicle GO:0008021 ISO
    perikaryon GO:0043204 IDA
    dendrite cytoplasm GO:0032839 IDA
 Experiment description of studies that identified Gria2 in exosomes
1
Experiment ID 30
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gria2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gria2 is involved
No pathways found





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