Gene description for NPC1L1
Gene name NPC1-like 1
Gene symbol NPC1L1
Other names/aliases NPC11L1
Species Homo sapiens
 Database cross references - NPC1L1
ExoCarta ExoCarta_29881
Vesiclepedia VP_29881
Entrez Gene 29881
HGNC 7898
MIM 608010
UniProt Q9UHC9  
 NPC1L1 identified in exosomes derived from the following tissue/cell type
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
 Gene ontology annotations for NPC1L1
Molecular Function
    protein binding GO:0005515 IPI
    vitamin E binding GO:0008431 IDA
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IDA
    small GTPase binding GO:0031267 IPI
    myosin V binding GO:0031489 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    cholesterol biosynthetic process GO:0006695 IMP
    sterol transport GO:0015918 IBA
    intestinal cholesterol absorption GO:0030299 IBA
    intestinal cholesterol absorption GO:0030299 IMP
    cholesterol transport GO:0030301 IMP
    lipoprotein metabolic process GO:0042157 IMP
    vitamin E metabolic process GO:0042360 IDA
    cholesterol homeostasis GO:0042632 IBA
    vitamin transport GO:0051180 IDA
    cellular response to sterol depletion GO:0071501 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
 Experiment description of studies that identified NPC1L1 in exosomes
1
Experiment ID 622
MISEV standards
EM
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 623
MISEV standards
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with IPMN with microinvasive cancer (IPMNca)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NPC1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LGR4 55366
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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