Gene description for Krt1
Gene name keratin 1, type II
Gene symbol Krt1
Other names/aliases Kb1
Species Rattus norvegicus
 Database cross references - Krt1
ExoCarta ExoCarta_300250
Vesiclepedia VP_300250
Entrez Gene 300250
UniProt Q6IMF3  
 Krt1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Krt1
Molecular Function
    carbohydrate binding GO:0030246 IEA
    carbohydrate binding GO:0030246 ISO
    structural constituent of skin epidermis GO:0030280 IBA
    structural constituent of skin epidermis GO:0030280 IEA
    structural constituent of skin epidermis GO:0030280 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
Biological Process
    complement activation, lectin pathway GO:0001867 IEA
    complement activation, lectin pathway GO:0001867 ISO
    biological_process GO:0008150 ND
    peptide cross-linking GO:0018149 ISO
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
    negative regulation of inflammatory response GO:0050728 IEA
    negative regulation of inflammatory response GO:0050728 ISO
    protein heterotetramerization GO:0051290 IEA
    protein heterotetramerization GO:0051290 ISO
    protein heterotetramerization GO:0051290 ISS
    establishment of skin barrier GO:0061436 IEA
    establishment of skin barrier GO:0061436 ISO
Subcellular Localization
    cornified envelope GO:0001533 IEA
    cornified envelope GO:0001533 ISO
    cornified envelope GO:0001533 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IEA
    keratin filament GO:0045095 ISO
 Experiment description of studies that identified Krt1 in exosomes
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Krt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Katna1  
Affinity Capture-MS Rattus norvegicus
2 Sumo3  
Affinity Capture-MS Rattus norvegicus
3 Ap2b1 140670
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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