Gene description for Tln1
Gene name talin 1
Gene symbol Tln1
Other names/aliases Tln
Species Rattus norvegicus
 Database cross references - Tln1
ExoCarta ExoCarta_313494
Entrez Gene 313494
 Tln1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tln1
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IEA
    insulin receptor binding GO:0005158 IEA
    integrin binding GO:0005178 ISO
    actin filament binding GO:0051015 IEA
    LIM domain binding GO:0030274 ISO
    protein complex binding GO:0032403 IPI
    vinculin binding GO:0017166 ISO
    molecular_function GO:0003674 ND
Biological Process
    platelet aggregation GO:0070527 ISO
    cell-substrate junction assembly GO:0007044 ISO
    cortical actin cytoskeleton organization GO:0030866 ISO
    cytoskeletal anchoring at plasma membrane GO:0007016 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    microtubule organizing center GO:0005815 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    ruffle GO:0001726 IEA
    focal adhesion GO:0005925 ISO
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Tln1 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tln1 is involved
No pathways found

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