Gene description for Itgb1
Gene name	integrin, beta 1
Gene symbol	Itgb1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Itgb1
ExoCarta	ExoCarta_24511
Vesiclepedia	VP_24511
Entrez Gene	24511
UniProt	P49134
Itgb1 identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Itgb1

Molecular Function     magnesium ion binding GO:0000287 ISO     fibronectin binding GO:0001968 IBA     fibronectin binding GO:0001968 IDA     fibronectin binding GO:0001968 ISO     protease binding GO:0002020 IPI     protease binding GO:0002020 ISO     actin binding GO:0003779 IDA     actin binding GO:0003779 ISO     signaling receptor binding GO:0005102 IPI     integrin binding GO:0005178 IBA     integrin binding GO:0005178 IMP     integrin binding GO:0005178 IPI     integrin binding GO:0005178 ISO     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     collagen binding GO:0005518 IDA     kinase binding GO:0019900 IPI     protein kinase binding GO:0019901 IBA     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IDA     C-X3-C chemokine binding GO:0019960 IBA     C-X3-C chemokine binding GO:0019960 ISO     C-X3-C chemokine binding GO:0019960 ISS     signaling receptor activity GO:0038023 IEA     signaling receptor activity GO:0038023 ISO     laminin binding GO:0043236 IBA     laminin binding GO:0043236 IDA     laminin binding GO:0043236 IEA     laminin binding GO:0043236 IMP     laminin binding GO:0043236 ISO     protein-containing complex binding GO:0044877 IMP     protein-containing complex binding GO:0044877 IPI     protein-containing complex binding GO:0044877 ISO     protein heterodimerization activity GO:0046982 ISO     cell adhesion molecule binding GO:0050839 ISO     alpha-actinin binding GO:0051393 IDA     collagen binding involved in cell-matrix adhesion GO:0098639 IBA     collagen binding involved in cell-matrix adhesion GO:0098639 ISO     integrin binding involved in cell-matrix adhesion GO:0098640 IEA     integrin binding involved in cell-matrix adhesion GO:0098640 ISO     integrin binding involved in cell-matrix adhesion GO:0098640 ISS     protein tyrosine kinase binding GO:1990782 ISO Biological Process     G1/S transition of mitotic cell cycle GO:0000082 IEA     G1/S transition of mitotic cell cycle GO:0000082 ISO     establishment of mitotic spindle orientation GO:0000132 ISO     angiogenesis GO:0001525 ISO     in utero embryonic development GO:0001701 IEA     in utero embryonic development GO:0001701 ISO     tissue homeostasis GO:0001894 IMP     cell migration involved in sprouting angiogenesis GO:0002042 IEA     cell migration involved in sprouting angiogenesis GO:0002042 ISO     positive regulation of neuroblast proliferation GO:0002052 IEA     positive regulation of neuroblast proliferation GO:0002052 ISO     phagocytosis GO:0006909 IMP     cell adhesion GO:0007155 IEA     cell adhesion GO:0007155 ISO     leukocyte cell-cell adhesion GO:0007159 ISO     cell-matrix adhesion GO:0007160 IBA     cell-matrix adhesion GO:0007160 IEA     cell-matrix adhesion GO:0007160 ISO     cell-matrix adhesion GO:0007160 ISO     calcium-independent cell-matrix adhesion GO:0007161 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 IEA     integrin-mediated signaling pathway GO:0007229 ISO     neuroblast proliferation GO:0007405 IEA     neuroblast proliferation GO:0007405 ISO     muscle organ development GO:0007517 IEA     myoblast fusion GO:0007520 ISS     regulation of G protein-coupled receptor signaling pathway GO:0008277 IMP     cell population proliferation GO:0008283 ISO     negative regulation of cell population proliferation GO:0008285 IMP     germ cell migration GO:0008354 IEA     germ cell migration GO:0008354 ISO     visual learning GO:0008542 IEA     visual learning GO:0008542 ISO     response to xenobiotic stimulus GO:0009410 IEP     regulation of collagen catabolic process GO:0010710 ISO     regulation of collagen catabolic process GO:0010710 ISS     positive regulation of fibroblast migration GO:0010763 ISO     positive regulation of cell-substrate adhesion GO:0010811 IMP     positive regulation of neuron projection development GO:0010976 IMP     response to activity GO:0014823 IEP     response to muscle activity GO:0014850 IEA     response to muscle activity GO:0014850 ISO     cell migration GO:0016477 IBA     formation of radial glial scaffolds GO:0021943 IEA     formation of radial glial scaffolds GO:0021943 ISO     CD40 signaling pathway GO:0023035 ISO     cell projection organization GO:0030030 IMP     lamellipodium assembly GO:0030032 IMP     neuron differentiation GO:0030182 ISO     positive regulation of cell migration GO:0030335 IMP     neuron projection development GO:0031175 ISO     negative regulation of cell projection organization GO:0031345 IMP     cell-substrate adhesion GO:0031589 ISO     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     receptor internalization GO:0031623 ISS     response to nutrient levels GO:0031667 IEP     protein transport within lipid bilayer GO:0032594 IMP     cell adhesion mediated by integrin GO:0033627 IBA     cell adhesion mediated by integrin GO:0033627 IGI     cell adhesion mediated by integrin GO:0033627 ISO     cell adhesion mediated by integrin GO:0033627 ISS     cell-cell adhesion mediated by integrin GO:0033631 ISO     heterotypic cell-cell adhesion GO:0034113 ISO     response to gonadotropin GO:0034698 IEP     negative regulation of Rho protein signal transduction GO:0035024 IEA     negative regulation of Rho protein signal transduction GO:0035024 ISO     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IDA     stress fiber assembly GO:0043149 ISO     positive regulation of GTPase activity GO:0043547 ISO     sarcomere organization GO:0045214 IEA     sarcomere organization GO:0045214 ISO     myoblast differentiation GO:0045445 ISS     negative regulation of neuron differentiation GO:0045665 IEA     negative regulation of neuron differentiation GO:0045665 IMP     negative regulation of neuron differentiation GO:0045665 ISO     positive regulation of neuron differentiation GO:0045666 IMP     positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 ISO     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of endocytosis GO:0045807 IMP     negative regulation of vasoconstriction GO:0045906 ISO     negative regulation of vasoconstriction GO:0045906 ISS     mesodermal cell differentiation GO:0048333 ISO     myoblast fate specification GO:0048626 IEA     myoblast fate specification GO:0048626 ISO     axon extension GO:0048675 IEA     axon extension GO:0048675 ISO     dendrite morphogenesis GO:0048813 IEA     dendrite morphogenesis GO:0048813 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP     modulation of chemical synaptic transmission GO:0050804 ISO     leukocyte tethering or rolling GO:0050901 ISO     regulation of cell cycle GO:0051726 IEA     regulation of cell cycle GO:0051726 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of glutamate uptake involved in transmission of nerve impulse GO:0051951 IEA     positive regulation of glutamate uptake involved in transmission of nerve impulse GO:0051951 ISO     cardiac muscle cell differentiation GO:0055007 IEA     cardiac muscle cell differentiation GO:0055007 ISO     maternal process involved in female pregnancy GO:0060135 IEP     cardiac muscle cell myoblast differentiation GO:0060379 IEA     cardiac muscle cell myoblast differentiation GO:0060379 ISO     cardiac cell fate specification GO:0060912 IEA     cardiac cell fate specification GO:0060912 ISO     bicellular tight junction assembly GO:0070830 IMP     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to vitamin D GO:0071305 IEP     cellular response to low-density lipoprotein particle stimulus GO:0071404 IEA     cellular response to low-density lipoprotein particle stimulus GO:0071404 ISO     cellular response to low-density lipoprotein particle stimulus GO:0071404 ISS     cellular response to ionizing radiation GO:0071479 IEP     response to transforming growth factor beta GO:0071559 IEP     basement membrane organization GO:0071711 IEA     basement membrane organization GO:0071711 ISO     positive regulation of wound healing GO:0090303 ISO     establishment of Sertoli cell barrier GO:0097368 IEP     cell-cell adhesion GO:0098609 IBA     maintenance of postsynaptic specialization structure GO:0098880 EXP     maintenance of postsynaptic specialization structure GO:0098880 IDA     synaptic membrane adhesion to extracellular matrix GO:0099561 IC     regulation of spontaneous synaptic transmission GO:0150003 IEA     regulation of spontaneous synaptic transmission GO:0150003 ISO     regulation of postsynaptic neurotransmitter receptor diffusion trapping GO:0150054 EXP     regulation of postsynaptic neurotransmitter receptor diffusion trapping GO:0150054 IDA     reactive gliosis GO:0150103 IEA     reactive gliosis GO:0150103 ISO     positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISO     regulation of inward rectifier potassium channel activity GO:1901979 ISO     positive regulation of protein localization to plasma membrane GO:1903078 ISO     positive regulation of protein localization to plasma membrane GO:1903078 ISS     regulation of synapse pruning GO:1905806 IEA     regulation of synapse pruning GO:1905806 ISO     negative regulation of anoikis GO:2000811 ISO Subcellular Localization     acrosomal vesicle GO:0001669 IDA     basement membrane GO:0005604 IDA     cytoplasm GO:0005737 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell-cell junction GO:0005911 IDA     adherens junction GO:0005912 IDA     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 IDA     focal adhesion GO:0005925 ISO     integrin complex GO:0008305 IBA     integrin complex GO:0008305 IDA     external side of plasma membrane GO:0009897 IEA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IBA     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     intercalated disc GO:0014704 IEA     intercalated disc GO:0014704 ISO     membrane GO:0016020 ISO     lamellipodium GO:0030027 IEA     hemidesmosome GO:0030056 IDA     filopodium GO:0030175 ISO     cytoplasmic vesicle GO:0031410 ISO     neuromuscular junction GO:0031594 IEA     neuromuscular junction GO:0031594 ISO     ruffle membrane GO:0032587 IEA     ruffle membrane GO:0032587 ISO     integrin alpha1-beta1 complex GO:0034665 ISO     integrin alpha2-beta1 complex GO:0034666 ISO     integrin alpha3-beta1 complex GO:0034667 IDA     integrin alpha3-beta1 complex GO:0034667 ISO     integrin alpha4-beta1 complex GO:0034668 ISO     integrin alpha5-beta1 complex GO:0034674 ISO     integrin alpha6-beta1 complex GO:0034675 ISO     integrin alpha7-beta1 complex GO:0034677 IEA     integrin alpha7-beta1 complex GO:0034677 ISO     integrin alpha9-beta1 complex GO:0034679 IDA     integrin alpha9-beta1 complex GO:0034679 IEA     integrin alpha9-beta1 complex GO:0034679 ISO     integrin alpha10-beta1 complex GO:0034680 ISO     integrin alpha11-beta1 complex GO:0034681 ISO     integrin alphav-beta1 complex GO:0034682 ISO     myelin sheath abaxonal region GO:0035748 IEA     myelin sheath abaxonal region GO:0035748 ISO     sarcolemma GO:0042383 IEA     sarcolemma GO:0042383 ISO     melanosome GO:0042470 IEA     dendritic spine GO:0043197 IEA     dendritic spine GO:0043197 ISO     receptor complex GO:0043235 ISO     membrane raft GO:0045121 ISO     synapse GO:0045202 IBA     synapse GO:0045202 ISO     postsynaptic membrane GO:0045211 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     recycling endosome GO:0055037 IEA     anchoring junction GO:0070161 IEA     synaptic membrane GO:0097060 IEA     synaptic membrane GO:0097060 ISO     synaptic membrane GO:0097060 ISO     glial cell projection GO:0097386 IDA     Schaffer collateral - CA1 synapse GO:0098685 IEA     Schaffer collateral - CA1 synapse GO:0098685 ISO     glycinergic synapse GO:0098690 EXP     glycinergic synapse GO:0098690 IDA     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 ISO     cerebellar climbing fiber to Purkinje cell synapse GO:0150053 IEA     cerebellar climbing fiber to Purkinje cell synapse GO:0150053 ISO