Gene description for Pen
Gene name Pendulin
Gene symbol Pen
Other names/aliases 2.1
CG4799
DPend
Dalpha2
Dimp-alpha2
DmelCG4799
IMPalpha2
Imp-alpha2
Kap alpha2
Kap-alpha2
Kpna2
OHO31
Oho31
Rch1
alpha2
alpha2A-Kap
alphaKap2
anon-WO0140519.258
bs29g06.y1
imp alpha2
imp-alpha2
impalpha2
importin alpha2/pendulin
l(2)144/1
l(2)k14401
oho-31
oho31
pen
pen-2
Species Drosophila melanogaster
 Database cross references - Pen
ExoCarta ExoCarta_34338
Vesiclepedia VP_34338
Entrez Gene 34338
UniProt P52295  
 Pen identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Pen
Biological Process
    NLS-bearing protein import into nucleus GO:0006607 IMP
    sperm individualization GO:0007291 IMP
    female germline ring canal formation GO:0007301 IMP
    gravitaxis GO:0042332 IMP
    lymph gland development GO:0048542 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Pen in exosomes
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pen
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cyp12d1-p  
Affinity Capture-MS Drosophila melanogaster
2 CG12155  
Two-hybrid Drosophila melanogaster
3 Cas  
Two-hybrid Drosophila melanogaster
4 CG13090  
Two-hybrid Drosophila melanogaster
5 CG1888  
Two-hybrid Drosophila melanogaster
6 Usp7  
Two-hybrid Drosophila melanogaster
7 Tango6  
Two-hybrid Drosophila melanogaster
8 CG11275  
Two-hybrid Drosophila melanogaster
9 Map60  
Two-hybrid Drosophila melanogaster
10 CG17259  
Affinity Capture-MS Drosophila melanogaster
11 Nup153  
Affinity Capture-MS Drosophila melanogaster
12 prod  
Two-hybrid Drosophila melanogaster
13 l(2)05714  
Two-hybrid Drosophila melanogaster
14 tx  
Two-hybrid Drosophila melanogaster
15 Sucb  
Affinity Capture-MS Drosophila melanogaster
16 CG17271  
Two-hybrid Drosophila melanogaster
17 CG15646  
Two-hybrid Drosophila melanogaster
18 Aats-asp  
Affinity Capture-MS Drosophila melanogaster
19 MRP  
Affinity Capture-MS Drosophila melanogaster
20 CG3902  
Affinity Capture-MS Drosophila melanogaster
21 CG3225  
Two-hybrid Drosophila melanogaster
22 RpS18 37292
Two-hybrid Drosophila melanogaster
23 Fak  
Two-hybrid Drosophila melanogaster
24 Dip2  
Two-hybrid Drosophila melanogaster
25 Cnx99A  
Affinity Capture-MS Drosophila melanogaster
26 insc  
Two-hybrid Drosophila melanogaster
27 Kap-alpha3  
Affinity Capture-MS Drosophila melanogaster
28 PebIII  
Two-hybrid Drosophila melanogaster
29 Dys  
Two-hybrid Drosophila melanogaster
30 BEAF-32  
Two-hybrid Drosophila melanogaster
31 Lam  
Two-hybrid Drosophila melanogaster
32 jigr1  
Two-hybrid Drosophila melanogaster
33 Nup50  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
34 TBPH  
Two-hybrid Drosophila melanogaster
35 cnc  
Two-hybrid Drosophila melanogaster
36 Ccn  
Two-hybrid Drosophila melanogaster
37 Pomp  
Two-hybrid Drosophila melanogaster
38 mbl  
Two-hybrid Drosophila melanogaster
39 CG14995  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml



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