Gene description for IL5
Gene name interleukin 5
Gene symbol IL5
Other names/aliases EDF
IL-5
TRF
Species Homo sapiens
 Database cross references - IL5
ExoCarta ExoCarta_3567
Vesiclepedia VP_3567
Entrez Gene 3567
HGNC 6016
MIM 147850
UniProt P05113  
 IL5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL5
Molecular Function
    cytokine activity GO:0005125 IDA
    interleukin-5 receptor binding GO:0005137 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
Biological Process
    positive regulation of immunoglobulin production GO:0002639 IEA
    inflammatory response GO:0006954 TAS
    immune response GO:0006955 IEA
    positive regulation of B cell proliferation GO:0030890 IEA
    interleukin-5-mediated signaling pathway GO:0038043 IDA
    positive regulation of eosinophil differentiation GO:0045645 IEA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
    positive regulation of podosome assembly GO:0071803 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 TAS
 Experiment description of studies that identified IL5 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL5 3567
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
2 IL5RA  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
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