Gene description for Tom1
Gene name target of myb1 (chicken)
Gene symbol Tom1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Tom1
ExoCarta ExoCarta_361370
Vesiclepedia VP_361370
Entrez Gene 361370
 Tom1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Tom1
Molecular Function
    phosphatidylinositol-5-phosphate binding GO:0010314 ISO
    clathrin binding GO:0030276 IBA
    clathrin binding GO:0030276 ISO
    polyubiquitin modification-dependent protein binding GO:0031593 ISO
    clathrin heavy chain binding GO:0032050 ISO
    ubiquitin binding GO:0043130 ISO
    myosin VI binding GO:0070853 ISO
Biological Process
    signal transduction GO:0007165 IBA
    protein transport GO:0015031 IEA
    endosomal transport GO:0016197 ISO
    substrate localization to autophagosome GO:0061753 ISO
    autophagosome-lysosome fusion GO:0061909 ISO
    positive regulation of autophagosome maturation GO:1901098 ISO
    regulation of endosome organization GO:1904978 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    early endosome GO:0005769 ISO
    cytosol GO:0005829 ISO
    endosome membrane GO:0010008 ISO
    membrane GO:0016020 IBA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Tom1 in exosomes
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Tom1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tollip 361677
Two-hybrid Rattus norvegicus
2 Ap2b1 140670
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Tom1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here