Gene description for Rangap1
Gene name RAN GTPase activating protein 1
Gene symbol Rangap1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rangap1
ExoCarta ExoCarta_362965
Vesiclepedia VP_362965
Entrez Gene 362965
 Rangap1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rangap1
Molecular Function
    RNA binding GO:0003723 ISO
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 ISO
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
    small GTPase binding GO:0031267 IDA
    small GTPase binding GO:0031267 ISO
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    signal transduction GO:0007165 IEA
    protein sumoylation GO:0016925 ISO
    negative regulation of protein export from nucleus GO:0046826 ISO
    response to axon injury GO:0048678 IEP
    nuclear export GO:0051168 IBA
    nuclear export GO:0051168 ISO
    cellular response to peptide hormone stimulus GO:0071375 IDA
    activation of GTPase activity GO:0090630 ISO
    cellular response to vasopressin GO:1904117 IEP
Subcellular Localization
    kinetochore GO:0000776 ISO
    nucleus GO:0005634 IBA
    nuclear envelope GO:0005635 ISO
    nuclear pore GO:0005643 IDA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    aggresome GO:0016235 IEA
    aggresome GO:0016235 ISO
    dendrite GO:0030425 IDA
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    nuclear pore cytoplasmic filaments GO:0044614 IDA
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 ISO
    mitotic spindle GO:0072686 IDA
    SUMO ligase complex GO:0106068 ISO
    axon cytoplasm GO:1904115 IDA
    cytoplasmic periphery of the nuclear pore complex GO:1990723 IDA
 Experiment description of studies that identified Rangap1 in exosomes
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rangap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ube2i  
Affinity Capture-Western Rattus norvegicus
2 Sumo3  
Affinity Capture-MS Rattus norvegicus
3 RAN 5901
Far Western Homo sapiens
4 Ap2b1 140670
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Rangap1 is involved
No pathways found





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