Gene description for KCNG1
Gene name potassium channel, voltage gated modifier subfamily G, member 1
Gene symbol KCNG1
Other names/aliases K13
KCNG
KV6.1
kH2
Species Homo sapiens
 Database cross references - KCNG1
ExoCarta ExoCarta_3755
Vesiclepedia VP_3755
Entrez Gene 3755
HGNC 6248
MIM 603788
UniProt Q9UIX4  
 KCNG1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCNG1
Molecular Function
    voltage-gated potassium channel activity GO:0005249 IEA
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 IDA
Biological Process
    action potential GO:0001508 IBA
    potassium ion transport GO:0006813 NAS
    protein homooligomerization GO:0051260 IEA
    potassium ion transmembrane transport GO:0071805 IBA
    regulation of potassium ion transmembrane transport GO:1901379 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    voltage-gated potassium channel complex GO:0008076 IBA
    voltage-gated potassium channel complex GO:0008076 IDA
    voltage-gated potassium channel complex GO:0008076 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified KCNG1 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZDHHC12  
Affinity Capture-MS Homo sapiens
2 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PYCRL 65263
Affinity Capture-MS Homo sapiens
4 TMED7 51014
Affinity Capture-MS Homo sapiens
5 MARCH4  
Affinity Capture-MS Homo sapiens
6 UBB 7314
Affinity Capture-MS Homo sapiens
7 DCST1  
Affinity Capture-MS Homo sapiens
8 SLC30A2  
Affinity Capture-MS Homo sapiens
9 KCNA2  
Affinity Capture-MS Homo sapiens
10 KCNB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
13 KCNB2  
Affinity Capture-MS Homo sapiens
14 CCDC107  
Affinity Capture-MS Homo sapiens
15 TLR9  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCNG1 is involved
PathwayEvidenceSource
Neuronal System TAS Reactome
Potassium Channels TAS Reactome
Voltage gated Potassium channels TAS Reactome





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