Gene description for KCNH1
Gene name potassium channel, voltage gated eag related subfamily H, member 1
Gene symbol KCNH1
Other names/aliases EAG
EAG1
Kv10.1
TMBTS
h-eag
Species Homo sapiens
 Database cross references - KCNH1
ExoCarta ExoCarta_3756
Vesiclepedia VP_3756
Entrez Gene 3756
HGNC 6250
MIM 603305
UniProt O95259  
 KCNH1 identified in exosomes derived from the following tissue/cell type
Cholangiocarcinoma cells 31054213    
Cholangiocarcinoma cells 31054213    
 Gene ontology annotations for KCNH1
Molecular Function
    phosphorelay sensor kinase activity GO:0000155 IEA
    cyclic nucleotide binding GO:0030551 ISS
    delayed rectifier potassium channel activity GO:0005251 IDA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
Biological Process
    regulation of ion transmembrane transport GO:0034765 IEA
    synaptic transmission GO:0007268 TAS
    regulation of cell proliferation GO:0042127 IMP
    signal transduction by protein phosphorylation GO:0023014 IEA
    regulation of membrane potential GO:0042391 IBA
    potassium ion transmembrane transport GO:0071805 IDA
    phosphorelay signal transduction system GO:0000160 IEA
    myoblast fusion GO:0007520 TAS
    potassium ion transport GO:0006813 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 IMP
    voltage-gated potassium channel complex GO:0008076 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 TAS
    early endosome membrane GO:0031901 IDA
    nuclear inner membrane GO:0005637 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified KCNH1 in exosomes
1
Experiment ID 1223
MISEV standards
EM
EV Biophysical techniques
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C.
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213 - in-gel digestion
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 1224
MISEV standards
EM
EV Biophysical techniques
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C.
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213D5 - in-gel digestion
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KCNH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNF1  
Two-hybrid Homo sapiens
2 KCNC1  
Two-hybrid Homo sapiens
3 ALG10  
Invitro Homo sapiens
4 KCNB1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which KCNH1 is involved
PathwayEvidenceSource
Voltage gated Potassium channels TAS Reactome





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