Gene description for pav
Gene name pavarotti
Gene symbol pav
Other names/aliases 0934/13
0973/08
2A12
2A12MEL
CG1258
DmKLP1/pav
DmMKLP1
DmPAV
DmPav
DmelCG1258
KIF 23
KIF23
Mklp1
PAV
PAV-KLP
PAV-MKLP
PAV/KLP
Pav
Pav KLP
Pav-KLP
Pav-Klp
Pav-klp
PavKLP
anon-EST:fe2A12
anon2A12
group D
pav-KLP
pav-Klp
Species Drosophila melanogaster
 Database cross references - pav
ExoCarta ExoCarta_38515
Vesiclepedia VP_38515
Entrez Gene 38515
 pav identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for pav
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitotic cytokinesis GO:0000281 IMP
    actomyosin contractile ring contraction GO:0000916 IMP
    cell fate determination GO:0001709 IMP
    mitotic spindle organization GO:0007052 IMP
    peripheral nervous system development GO:0007422 TAS
    somatic muscle development GO:0007525 IMP
    larval somatic muscle development GO:0007526 IGI
    maintenance of protein location in cell GO:0032507 IMP
    microtubule sliding GO:0051012 IMP
    regulation of microtubule cytoskeleton organization GO:0070507 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of neuron projection arborization GO:0150013 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    kinetochore microtubule GO:0005828 IDA
    axoneme GO:0005930 IDA
    midbody GO:0030496 IDA
    cleavage furrow GO:0032154 IDA
    male germline ring canal GO:0035323 IDA
    female germline ring canal GO:0035324 IDA
    contractile ring GO:0070938 IDA
    centralspindlin complex GO:0097149 IDA
    somatic ring canal GO:0098549 IDA
    mitotic spindle midzone GO:1990023 IDA
 Experiment description of studies that identified pav in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for pav
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hira  
Affinity Capture-MS Drosophila melanogaster
2 Srp72  
Affinity Capture-MS Drosophila melanogaster
3 Map205 43765
Affinity Capture-MS Drosophila melanogaster
4 CG32344  
Affinity Capture-MS Drosophila melanogaster
5 tum 36538
Affinity Capture-MS Drosophila melanogaster
6 CG8939  
Affinity Capture-MS Drosophila melanogaster
7 Dgp-1  
Affinity Capture-MS Drosophila melanogaster
8 l(1)G0020  
Affinity Capture-MS Drosophila melanogaster
9 Caf1  
Affinity Capture-MS Drosophila melanogaster
10 BicD  
Affinity Capture-MS Drosophila melanogaster
11 CG31368  
Two-hybrid Drosophila melanogaster
12 eIF-2beta  
Affinity Capture-MS Drosophila melanogaster
13 AP-2mu  
Affinity Capture-MS Drosophila melanogaster
14 pit  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which pav is involved
No pathways found





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