Gene description for pav
Gene name pavarotti
Gene symbol pav
Other names/aliases 0934/13
0973/08
2A12
2A12MEL
CG1258
DmKLP1/pav
DmMKLP1
DmPAV
DmPav
DmelCG1258
KIF 23
KIF23
Mklp1
PAV
PAV-KLP
PAV-MKLP
PAV/KLP
Pav
Pav KLP
Pav-KLP
Pav-Klp
Pav-klp
PavKLP
anon-EST:fe2A12
anon2A12
group D
pav-KLP
pav-Klp
Species Drosophila melanogaster
 Database cross references - pav
ExoCarta ExoCarta_38515
Entrez Gene 38515
 pav identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for pav
Molecular Function
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IEA
    microtubule motor activity GO:0003777 ISS
Biological Process
    female meiosis chromosome segregation GO:0016321 IMP
    mitotic spindle organization GO:0007052 IMP
    smoothened signaling pathway GO:0007224 IGI
    positive regulation of NFAT protein import into nucleus GO:0051533 IMP
    regulation of microtubule cytoskeleton organization GO:0070507 IMP
    microtubule bundle formation involved in mitotic spindle midzone assembly GO:1903562 IMP
    cytokinesis GO:0000910 NAS
    neurogenesis GO:0022008 IMP
    actomyosin contractile ring contraction GO:0000916 IMP
    actomyosin contractile ring assembly GO:0000915 NAS
    centrosome duplication GO:0051298 IMP
    mitotic spindle assembly GO:0090307 IMP
    somatic muscle development GO:0007525 IMP
    microtubule-based movement GO:0007018 ISS
    mitotic cytokinesis GO:0000281 IMP
    regulation of Wnt signaling pathway GO:0030111 IMP
    peripheral nervous system development GO:0007422 TAS
    maintenance of protein location in cell GO:0032507 IMP
    cell fate determination GO:0001709 IMP
Subcellular Localization
    kinetochore microtubule GO:0005828 IDA
    cleavage furrow GO:0032154 IDA
    centrosome GO:0005813 NAS
    nucleus GO:0005634 IDA
    midbody GO:0030496 IDA
    somatic ring canal GO:0098549 IDA
    axoneme GO:0005930 IDA
    male germline ring canal GO:0035323 IDA
    female germline ring canal GO:0035324 IDA
    mitotic spindle midzone GO:1990023 IDA
    kinesin complex GO:0005871 ISS
    spindle GO:0005819 NAS
    contractile ring GO:0070938 IDA
 Experiment description of studies that identified pav in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for pav
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which pav is involved
No pathways found





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