Gene description for THEMIS
Gene name thymocyte selection associated
Gene symbol THEMIS
Other names/aliases C6orf190
C6orf207
GASP
SPOT
TSEPA
bA325O24.3
bA325O24.4
Species Homo sapiens
 Database cross references - THEMIS
ExoCarta ExoCarta_387357
Vesiclepedia VP_387357
Entrez Gene 387357
HGNC 21569
MIM 613607
UniProt Q8N1K5  
 THEMIS identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for THEMIS
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    adaptive immune response GO:0002250 IEA
    positive T cell selection GO:0043368 ISS
    negative T cell selection GO:0043383 ISS
    T cell receptor signaling pathway GO:0050852 IBA
    T cell receptor signaling pathway GO:0050852 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cell-cell junction GO:0005911 IEA
    COP9 signalosome GO:0008180 ISS
 Experiment description of studies that identified THEMIS in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for THEMIS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PTPN11 5781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PRMT6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which THEMIS is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here