Gene description for SH3PX1
Gene name SH3PX1 ortholog (H. sapiens)
Gene symbol SH3PX1
Other names/aliases CG6757
DSH3PX
DSH3PX1
DmelCG6757
dSH3PX1
p63
Species Drosophila melanogaster
 Database cross references - SH3PX1
ExoCarta ExoCarta_39136
Vesiclepedia VP_39136
Entrez Gene 39136
 SH3PX1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for SH3PX1
Molecular Function
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IPI
    protein-macromolecule adaptor activity GO:0030674 IPI
Biological Process
    autophagosome assembly GO:0000045 IMP
    positive regulation of neurotransmitter secretion GO:0001956 IMP
    endosome organization GO:0007032 IMP
    lamellipodium assembly GO:0030032 IMP
    negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 IDA
    cellular response to hypoxia GO:0071456 IMP
    presynaptic active zone organization GO:1990709 IMP
Subcellular Localization
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 IDA
    cell cortex GO:0005938 IDA
    presynaptic membrane GO:0042734 IDA
    neuronal cell body GO:0043025 IDA
    terminal bouton GO:0043195 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    subsynaptic reticulum GO:0071212 IDA
    subsynaptic reticulum GO:0071212 IMP
 Experiment description of studies that identified SH3PX1 in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SH3PX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH3PX1 39136
Two-hybrid Drosophila melanogaster
Two-hybrid Drosophila melanogaster
2 CG13458  
Two-hybrid Drosophila melanogaster
3 Ack  
Two-hybrid Drosophila melanogaster
Affinity Capture-Western Drosophila melanogaster
Reconstituted Complex Drosophila melanogaster
Two-hybrid Drosophila melanogaster
4 CG12393  
Two-hybrid Drosophila melanogaster
5 scrib  
Two-hybrid Drosophila melanogaster
6 Irbp  
Two-hybrid Drosophila melanogaster
7 SmB  
Two-hybrid Drosophila melanogaster
8 CG17162  
Two-hybrid Drosophila melanogaster
9 Mlc2  
Two-hybrid Drosophila melanogaster
10 dock  
Affinity Capture-Western Drosophila melanogaster
Two-hybrid Drosophila melanogaster
11 tmod  
Two-hybrid Drosophila melanogaster
12 Leash  
Affinity Capture-MS Drosophila melanogaster
13 CG2641  
Affinity Capture-MS Drosophila melanogaster
14 Tab2  
Two-hybrid Drosophila melanogaster
15 CG44251  
Two-hybrid Drosophila melanogaster
16 CG5050  
Two-hybrid Drosophila melanogaster
17 CG14696  
Affinity Capture-MS Drosophila melanogaster
18 CG16717  
Two-hybrid Drosophila melanogaster
19 CG31038  
Two-hybrid Drosophila melanogaster
20 pros  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which SH3PX1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here