Gene description for SH3PX1
Gene name SH3PX1 ortholog (H. sapiens)
Gene symbol SH3PX1
Other names/aliases CG6757
DSH3PX
DSH3PX1
DmelCG6757
dSH3PX1
p63
Species Drosophila melanogaster
 Database cross references - SH3PX1
ExoCarta ExoCarta_39136
Entrez Gene 39136
 SH3PX1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for SH3PX1
Molecular Function
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IEA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
Biological Process
    autophagosome assembly GO:0000045 IMP
    phagosome-lysosome fusion involved in apoptotic cell clearance GO:0090389 IEA
    intracellular protein transport GO:0006886 ISS
    mitotic nuclear division GO:0007067 IEA
    cellular response to hypoxia GO:0071456 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    phagocytic vesicle GO:0045335 IEA
 Experiment description of studies that identified SH3PX1 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SH3PX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SH3PX1 is involved
No pathways found





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