Gene description for TSG101
Gene name Tumor susceptibility gene 101 ortholog (H. sapiens)
Gene symbol TSG101
Other names/aliases CG9712
DmTSG101
DmelCG9712
ESCRT-I
Ept
Tsg1-1
Tsg101
burs
dTSg101
dTsg101
dVps23
ept
tsg101
vps23
Species Drosophila melanogaster
 Database cross references - TSG101
ExoCarta ExoCarta_39881
Entrez Gene 39881
 TSG101 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for TSG101
Molecular Function
    ubiquitin binding GO:0043130 ISS
    protein binding GO:0005515 IPI
Biological Process
    trachea morphogenesis GO:0060439 IMP
    endosome transport via multivesicular body sorting pathway GO:0032509 IC
    terminal branching, open tracheal system GO:0007430 IMP
    protein transport GO:0015031 IEA
    epithelium development GO:0060429 IMP
    negative regulation of growth of symbiont in host GO:0044130 IMP
    germarium-derived egg chamber formation GO:0007293 IMP
    cellular protein modification process GO:0006464 IEA
    negative regulation of growth GO:0045926 IMP
    regulation of JAK-STAT cascade GO:0046425 IMP
    multivesicular body assembly GO:0036258 IMP
    negative regulation of imaginal disc growth GO:0045571 IMP
    maintenance of apical/basal cell polarity GO:0035090 IMP
Subcellular Localization
    ESCRT I complex GO:0000813 ISS
 Experiment description of studies that identified TSG101 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TSG101
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TSG101 is involved
No pathways found





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