Gene description for LPO
Gene name lactoperoxidase
Gene symbol LPO
Other names/aliases SPO
Species Homo sapiens
 Database cross references - LPO
ExoCarta ExoCarta_4025
Vesiclepedia VP_4025
Entrez Gene 4025
HGNC 6678
MIM 150205
UniProt P22079  
 LPO identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for LPO
Molecular Function
    heme binding GO:0020037 IEA
    thiocyanate peroxidase activity GO:0036393 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IDA
    hydrogen peroxide catabolic process GO:0042744 IEA
    defense response to bacterium GO:0042742 IDA
    oxidation-reduction process GO:0055114 IEA
    thiocyanate metabolic process GO:0018969 IEA
    response to oxidative stress GO:0006979 NAS
Subcellular Localization
    basolateral plasma membrane GO:0016323 IDA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified LPO in exosomes
1
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for LPO
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPO is involved
No pathways found





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