Gene description for LPO
Gene name lactoperoxidase
Gene symbol LPO
Other names/aliases SPO
Species Homo sapiens
 Database cross references - LPO
ExoCarta ExoCarta_4025
Vesiclepedia VP_4025
Entrez Gene 4025
HGNC 6678
MIM 150205
UniProt P22079  
 LPO identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for LPO
Molecular Function
    heme binding GO:0020037 IEA
    thiocyanate peroxidase activity GO:0036393 IBA
    thiocyanate peroxidase activity GO:0036393 IDA
    metal ion binding GO:0046872 IEA
    lactoperoxidase activity GO:0140825 IEA
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IDA
    response to oxidative stress GO:0006979 NAS
    thiocyanate metabolic process GO:0018969 IEA
    defense response to bacterium GO:0042742 IBA
    defense response to bacterium GO:0042742 IDA
    hydrogen peroxide catabolic process GO:0042744 IEA
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IEA
    basolateral plasma membrane GO:0016323 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified LPO in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for LPO
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NR3C1 2908
Proximity Label-MS Homo sapiens
2 TIMM10  
Affinity Capture-MS Homo sapiens
3 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here