Gene description for Rab11
Gene name CG5771 gene product from transcript CG5771-RA
Gene symbol Rab11
Other names/aliases AAF55850
CG5771
DRAB11
DRab11
Dm Rab11
DmRab11
DmelCG5771
Drab11
O18335
RAB11
Rab 11
Rab-11
Rab-r11
l(3)93Bi
l(3)j2D1
rab-11
rab11
rlr7
Species Drosophila melanogaster
 Database cross references - Rab11
ExoCarta ExoCarta_42501
Vesiclepedia VP_42501
Entrez Gene 42501
 Rab11 identified in sEVs derived from the following tissue/cell type
Embryonic cells 31666321    
Hemolymph 31666321    
Hemolymph 31666321    
 Gene ontology annotations for Rab11
Molecular Function
    GTPase activity GO:0003924 IMP
    protein binding GO:0005515 IPI
    GTPase activating protein binding GO:0032794 IPI
    protein-containing complex binding GO:0044877 IPI
Biological Process
    actomyosin contractile ring contraction GO:0000916 IMP
    compound eye morphogenesis GO:0001745 IMP
    antimicrobial peptide secretion GO:0002776 IMP
    endocytosis GO:0006897 IDA
    endocytosis GO:0006897 IMP
    male meiosis cytokinesis GO:0007112 IMP
    border follicle cell migration GO:0007298 IMP
    regulation of pole plasm oskar mRNA localization GO:0007317 IMP
    cellularization GO:0007349 IMP
    dorsal closure GO:0007391 IMP
    dorsal closure, elongation of leading edge cells GO:0007394 IMP
    oocyte microtubule cytoskeleton polarization GO:0008103 IMP
    vesicle-mediated transport GO:0016192 IMP
    sensory organ precursor cell fate determination GO:0016360 IMP
    chaeta development GO:0022416 IMP
    actin cytoskeleton organization GO:0030036 IMP
    follicle cell of egg chamber development GO:0030707 IMP
    germ-line stem cell population maintenance GO:0030718 IMP
    ovarian fusome organization GO:0030723 IMP
    cortical actin cytoskeleton organization GO:0030866 IMP
    endocytic recycling GO:0032456 IGI
    endocytic recycling GO:0032456 IMP
    Rab protein signal transduction GO:0032482 IDA
    adherens junction maintenance GO:0034334 IMP
    liquid clearance, open tracheal system GO:0035002 IMP
    rhabdomere development GO:0042052 IMP
    germ-line stem cell division GO:0042078 IMP
    positive regulation of Golgi to plasma membrane protein transport GO:0042998 IMP
    fusome organization GO:0045478 IMP
    dorsal closure, amnioserosa morphology change GO:0046664 IMP
    symbiont entry into host cell GO:0046718 HMP
    spermatocyte division GO:0048137 IMP
    Golgi vesicle fusion to target membrane GO:0048210 IMP
    synaptic vesicle endocytosis GO:0048488 IGI
    oocyte development GO:0048599 IMP
    compound eye development GO:0048749 IGI
    regulation of synapse organization GO:0050807 IMP
    centrosome localization GO:0051642 IMP
    protein localization to membrane GO:0072657 IDA
    exosomal secretion GO:1990182 IMP
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IDA
    autophagosome GO:0005776 IDA
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IDA
    microtubule organizing center GO:0005815 IDA
    plasma membrane GO:0005886 HDA
    trans-Golgi network transport vesicle GO:0030140 IDA
    cytoplasmic vesicle GO:0031410 IDA
    vesicle GO:0031982 IDA
    dense core granule membrane GO:0032127 IDA
    cleavage furrow GO:0032154 IDA
    neuronal cell body GO:0043025 HDA
    terminal bouton GO:0043195 IDA
    fusome GO:0045169 IDA
    synapse GO:0045202 HDA
    synapse GO:0045202 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    recycling endosome GO:0055037 IDA
    recycling endosome GO:0055037 IDA
    cell pole GO:0060187 IDA
    spindle envelope GO:0070732 IDA
 Experiment description of studies that identified Rab11 in sEVs
1
Experiment ID 1227
MISEV standards
Biophysical techniques
TSG101|Rab11
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Embryonic cells
Sample name S2
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study RT-PCR
Western blotting
2
Experiment ID 1228
MISEV standards
Biophysical techniques
TSG101|Rab11
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Hemolymph
Sample name Circulating hemolymph
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study RT-PCR
Western blotting
3
Experiment ID 1229
MISEV standards
Biophysical techniques
TSG101|Rab11
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Hemolymph
Sample name Circulating hemolymph
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Rab11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Yp2  
Affinity Capture-MS Drosophila melanogaster
2 phyl  
Two-hybrid Drosophila melanogaster
3 CG31343  
Affinity Capture-MS Drosophila melanogaster
4 CG16826  
Affinity Capture-MS Drosophila melanogaster
5 CG5500  
Affinity Capture-MS Drosophila melanogaster
6 betaTub56D  
Two-hybrid Drosophila melanogaster
7 Arf79F  
Affinity Capture-MS Drosophila melanogaster
8 skap  
Affinity Capture-MS Drosophila melanogaster
9 TER94  
Affinity Capture-MS Drosophila melanogaster
10 zuc  
Proximity Label-MS Drosophila melanogaster
11 Tom20  
Proximity Label-MS Drosophila melanogaster
12 Vha68-2  
Affinity Capture-MS Drosophila melanogaster
13 CG14894  
Proximity Label-MS Drosophila melanogaster
14 borr  
Two-hybrid Drosophila melanogaster
15 Mdh2  
Affinity Capture-MS Drosophila melanogaster
16 Pglym78  
Affinity Capture-MS Drosophila melanogaster
17 scu  
Affinity Capture-MS Drosophila melanogaster
18 betaTub85D  
Affinity Capture-MS Drosophila melanogaster
19 RpLP1  
Two-hybrid Drosophila melanogaster
20 nuf  
Two-hybrid Drosophila melanogaster
21 sisA  
Two-hybrid Drosophila melanogaster
22 CG11076  
Two-hybrid Drosophila melanogaster
23 Rab2  
Affinity Capture-MS Drosophila melanogaster
24 RpS15Ab  
Affinity Capture-MS Drosophila melanogaster
25 Phb2  
Affinity Capture-MS Drosophila melanogaster
26 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
27 Gdi 34264
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Rab11 is involved
No pathways found





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