Gene description for IQSEC3
Gene name IQ motif and Sec7 domain 3
Gene symbol IQSEC3
Other names/aliases -
Species Homo sapiens
 Database cross references - IQSEC3
ExoCarta ExoCarta_440073
Vesiclepedia VP_440073
Entrez Gene 440073
HGNC 29193
MIM 612118
UniProt Q9UPP2  
 IQSEC3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IQSEC3
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
Biological Process
    actin cytoskeleton organization GO:0030036 IBA
    regulation of ARF protein signal transduction GO:0032012 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    postsynaptic density GO:0014069 ISS
    postsynaptic membrane GO:0045211 IEA
    inhibitory synapse GO:0060077 IEA
    glycinergic synapse GO:0098690 IEA
    GABA-ergic synapse GO:0098982 IEA
    postsynaptic specialization of symmetric synapse GO:0099629 IEA
 Experiment description of studies that identified IQSEC3 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IQSEC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
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