Gene description for IQSEC3
Gene name IQ motif and Sec7 domain 3
Gene symbol IQSEC3
Other names/aliases -
Species Homo sapiens
 Database cross references - IQSEC3
ExoCarta ExoCarta_440073
Entrez Gene 440073
HGNC 29193
MIM 612118
UniProt Q9UPP2  
 IQSEC3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IQSEC3
Molecular Function
    ARF guanyl-nucleotide exchange factor activity GO:0005086 IBA
Biological Process
    vesicle-mediated transport GO:0016192 IBA
    actin cytoskeleton organization GO:0030036 IBA
    positive regulation of GTPase activity GO:0043547 IEA
Subcellular Localization
    trans-Golgi network GO:0005802 IBA
    inhibitory synapse GO:0060077 IEA
    postsynaptic membrane GO:0045211 IEA
 Experiment description of studies that identified IQSEC3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IQSEC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IQSEC3 is involved
No pathways found





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