Gene description for msk
Gene name moleskin
Gene symbol msk
Other names/aliases 61
CG7935
CIP-61
DIM-7
Dim-7
Dim7
DmRanBP7
DmelCG7935
Imp7
Imp7/8
Msk
S(ls)2
dim-7
dim7
Species Drosophila melanogaster
 Database cross references - msk
ExoCarta ExoCarta_44747
Entrez Gene 44747
 msk identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for msk
Molecular Function
    U4 snRNA binding GO:0030621 IDA
    Ran GTPase binding GO:0008536 ISS
    U1 snRNA binding GO:0030619 IDA
    protein binding GO:0005515 IPI
    U2 snRNA binding GO:0030620 IDA
    protein transmembrane transporter activity GO:0008320 ISS
Biological Process
    muscle attachment GO:0016203 IMP
    snRNP protein import into nucleus GO:0006608 IMP
    rhabdomere development GO:0042052 IMP
    ommatidial rotation GO:0016318 IMP
    protein import into nucleus GO:0006606 TAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IPI
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    compound eye cone cell differentiation GO:0042675 IMP
    imaginal disc-derived wing vein morphogenesis GO:0008586 IMP
    lateral inhibition GO:0046331 IMP
    cell proliferation GO:0008283 IMP
    R8 cell differentiation GO:0045465 IMP
    wing cell fate specification GO:0035311 IMP
    MAPK import into nucleus GO:0000189 IMP
    compound eye development GO:0048749 IMP
    imaginal disc-derived wing vein specification GO:0007474 IMP
    epidermal growth factor receptor signaling pathway GO:0007173 IGI
    Cajal body organization GO:0030576 IMP
Subcellular Localization
    cell cortex GO:0005938 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    Cajal body GO:0015030 IDA
    nuclear pore GO:0005643 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified msk in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for msk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which msk is involved
No pathways found





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