Gene description for msk
Gene name moleskin
Gene symbol msk
Other names/aliases 61
CG7935
CIP-61
DIM-7
Dim-7
Dim7
DmRanBP7
DmelCG7935
Imp7
Imp7/8
Msk
S(ls)2
dim-7
dim7
Species Drosophila melanogaster
 Database cross references - msk
ExoCarta ExoCarta_44747
Vesiclepedia VP_44747
Entrez Gene 44747
 msk identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for msk
Molecular Function
    protein binding GO:0005515 IPI
    U1 snRNA binding GO:0030619 IDA
    U2 snRNA binding GO:0030620 IDA
    U4 snRNA binding GO:0030621 IDA
Biological Process
    protein import into nucleus GO:0006606 IDA
    protein import into nucleus GO:0006606 IMP
    imaginal disc-derived wing vein specification GO:0007474 IMP
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    imaginal disc-derived wing vein morphogenesis GO:0008586 IMP
    muscle attachment GO:0016203 IGI
    muscle attachment GO:0016203 IMP
    ommatidial rotation GO:0016318 IMP
    Cajal body organization GO:0030576 IMP
    wing cell fate specification GO:0035311 IMP
    rhabdomere development GO:0042052 IMP
    compound eye cone cell differentiation GO:0042675 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    R8 cell differentiation GO:0045465 IMP
    compound eye development GO:0048749 IGI
    compound eye development GO:0048749 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 HDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 HDA
    cytosol GO:0005829 IDA
    cell cortex GO:0005938 IDA
    Cajal body GO:0015030 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified msk in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for msk
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTPsyn  
Proximity Label-MS Drosophila melanogaster
2 CG10417  
Affinity Capture-MS Drosophila melanogaster
3 CG12769  
Affinity Capture-MS Drosophila melanogaster
4 Aats-glupro 42834
Affinity Capture-MS Drosophila melanogaster
5 Mpcp  
Affinity Capture-MS Drosophila melanogaster
6 csw  
Affinity Capture-Western Drosophila melanogaster
7 fl(2)d  
Affinity Capture-MS Drosophila melanogaster
8 Cand1  
Affinity Capture-MS Drosophila melanogaster
9 MRP  
Affinity Capture-MS Drosophila melanogaster
10 CG18745  
Affinity Capture-MS Drosophila melanogaster
11 Ranbp9  
Affinity Capture-MS Drosophila melanogaster
12 Acsl  
Affinity Capture-MS Drosophila melanogaster
13 rpr  
Two-hybrid Drosophila melanogaster
14 CG1105  
Affinity Capture-MS Drosophila melanogaster
15 Sec63  
Affinity Capture-MS Drosophila melanogaster
16 rl  
Affinity Capture-Western Drosophila melanogaster
View the network image/svg+xml
 Pathways in which msk is involved
No pathways found





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