Gene description for Men
Gene name Malic enzyme
Gene symbol Men
Other names/aliases CG10120
DmelCG10120
MDH
ME
MEN
Mdh-NADP
Me
anon-WO0118547.278
mem
men
Species Drosophila melanogaster
 Database cross references - Men
ExoCarta ExoCarta_47173
Vesiclepedia VP_47173
Entrez Gene 47173
 Men identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Men
Molecular Function
    malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473 IDA
    malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473 IMP
Biological Process
    malate metabolic process GO:0006108 IMP
    NADH metabolic process GO:0006734 IDA
    NADPH regeneration GO:0006740 IDA
    determination of adult lifespan GO:0008340 IMP
    sleep GO:0030431 IMP
    negative regulation of apoptotic signaling pathway GO:2001234 IMP
Subcellular Localization
    cytosol GO:0005829 HDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Men in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Men
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Syb  
Affinity Capture-MS Drosophila melanogaster
2 Ir60a  
Two-hybrid Drosophila melanogaster
3 ci  
Two-hybrid Drosophila melanogaster
4 CG15177  
Two-hybrid Drosophila melanogaster
5 Tom20  
Proximity Label-MS Drosophila melanogaster
6 Moe  
Affinity Capture-MS Drosophila melanogaster
7 dl  
Two-hybrid Drosophila melanogaster
8 Fim 32721
Affinity Capture-MS Drosophila melanogaster
9 zuc  
Proximity Label-MS Drosophila melanogaster
10 CG17337  
Affinity Capture-MS Drosophila melanogaster
11 Akap200  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Men is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here