Gene description for NKX6-1
Gene name	NK6 homeobox 1
Gene symbol	NKX6-1
Other names/aliases	NKX6.1 NKX6A
Species	Homo sapiens
Database cross references - NKX6-1
ExoCarta	ExoCarta_4825
Entrez Gene	4825
HGNC	7839
MIM	602563
UniProt	P78426
NKX6-1 identified in exosomes derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for NKX6-1

Molecular Function     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IEA     chromatin binding GO:0003682 IEA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA Biological Process     smoothened signaling pathway GO:0007224 IEA     endocrine pancreas development GO:0031018 TAS     positive regulation of neuron differentiation GO:0045666 IEA     response to nicotine GO:0035094 IEA     type B pancreatic cell maturation GO:0072560 ISS     regulation of axon extension GO:0030516 IEA     positive regulation of glial cell differentiation GO:0045687 IEA     pancreas development GO:0031016 ISS     transcription from RNA polymerase II promoter GO:0006366 IEA     cellular response to peptide hormone stimulus GO:0071375 IEA     organ morphogenesis GO:0009887 TAS     cellular response to cytokine stimulus GO:0071345 IEA     positive regulation of insulin secretion GO:0032024 IEA     oligodendrocyte differentiation GO:0048709 IEA     response to drug GO:0042493 IEA     regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912 IEA     regulation of neuron migration GO:2001222 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     detection of glucose GO:0051594 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISS     positive regulation of type B pancreatic cell development GO:2000078 ISS     cell proliferation GO:0008283 IEA     negative regulation of glial cell differentiation GO:0045686 IEA     regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913 IEA Subcellular Localization     extracellular exosome GO:0070062 IDA     nucleoplasm GO:0005654 IDA