Gene description for Txnrd1
Gene name thioredoxin reductase 1
Gene symbol Txnrd1
Other names/aliases TR
TR1
TrxR1
Species Mus musculus
 Database cross references - Txnrd1
ExoCarta ExoCarta_50493
Vesiclepedia VP_50493
Entrez Gene 50493
UniProt Q9JMH6  
 Txnrd1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Txnrd1
Molecular Function
    flavin adenine dinucleotide binding GO:0050660 IEA
    oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor GO:0016668 IEA
    oxidoreductase activity GO:0016491 IEA
    protein homodimerization activity GO:0042803 ISO
    thioredoxin-disulfide reductase activity GO:0004791 ISO
    selenate reductase activity GO:0033797 ISO
    NAD(P)H oxidase activity GO:0016174 ISO
    mercury ion binding GO:0045340 ISO
Biological Process
    selenocysteine metabolic process GO:0016259 ISO
    NADPH oxidation GO:0070995 ISO
    benzene-containing compound metabolic process GO:0042537 ISO
    gastrulation GO:0007369 IMP
    positive regulation of cell death GO:0010942 ISO
    cell proliferation GO:0008283 IMP
    cell redox homeostasis GO:0045454 IEA
    response to oxidative stress GO:0006979 ISO
    protein tetramerization GO:0051262 ISO
    oxidation-reduction process GO:0055114 IDA
    mesoderm formation GO:0001707 IMP
    hydrogen peroxide catabolic process GO:0042744 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 ISO
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 IDA
    neuronal cell body GO:0043025 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Txnrd1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Txnrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Txnrd1 is involved
No pathways found





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