Gene description for Txnrd1
Gene name thioredoxin reductase 1
Gene symbol Txnrd1
Other names/aliases TR
TR1
TrxR1
Species Mus musculus
 Database cross references - Txnrd1
ExoCarta ExoCarta_50493
Vesiclepedia VP_50493
Entrez Gene 50493
UniProt Q9JMH6  
 Txnrd1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Txnrd1
Molecular Function
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 IBA
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 IDA
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 ISO
    NAD(P)H oxidase H2O2-forming activity GO:0016174 ISO
    selenate reductase activity GO:0033797 ISO
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    mercury ion binding GO:0045340 ISO
    NADPH peroxidase activity GO:0050137 ISO
    NADPH peroxidase activity GO:0050137 ISS
    FAD binding GO:0071949 ISO
    FAD binding GO:0071949 ISS
Biological Process
    mesoderm formation GO:0001707 IMP
    response to oxidative stress GO:0006979 ISO
    gastrulation GO:0007369 IMP
    cell population proliferation GO:0008283 IMP
    selenocysteine metabolic process GO:0016259 ISO
    benzene-containing compound metabolic process GO:0042537 ISO
    hydrogen peroxide catabolic process GO:0042744 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    cell redox homeostasis GO:0045454 IBA
    cell redox homeostasis GO:0045454 IEA
    NADPH oxidation GO:0070995 ISO
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    neuronal cell body GO:0043025 ISO
 Experiment description of studies that identified Txnrd1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Txnrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Apex1  
Co-fractionation Mus musculus
2 Nae1  
Co-fractionation Mus musculus
3 Glrx2  
Co-fractionation Mus musculus
4 Ubxn1  
Co-fractionation Mus musculus
5 Isg15  
Co-fractionation Mus musculus
6 Txndc17  
Co-fractionation Mus musculus
7 Tnpo1 238799
Co-fractionation Mus musculus
8 Ipo5 70572
Co-fractionation Mus musculus
View the network image/svg+xml



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