Gene description for Ipo5
Gene name importin 5
Gene symbol Ipo5
Other names/aliases 1110011C18Rik
5730478E03Rik
AA409333
C76941
IMB3
Kpnb3
Ranbp5
Species Mus musculus
 Database cross references - Ipo5
ExoCarta ExoCarta_70572
Entrez Gene 70572
UniProt Q8BKC5  
 Ipo5 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Ipo5
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    protein transporter activity GO:0008565 IDA
    Ran GTPase binding GO:0008536 IEA
    protein binding GO:0005515 IPI
Biological Process
    NLS-bearing protein import into nucleus GO:0006607 IDA
    ribosomal protein import into nucleus GO:0006610 ISO
    intracellular protein transport GO:0006886 IEA
    protein transport GO:0015031 IEA
    positive regulation of protein import into nucleus GO:0042307 IMP
    transport GO:0006810 IEA
    cellular response to amino acid stimulus GO:0071230 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 ISO
    nucleoplasm GO:0005654 ISO
    membrane GO:0016020 ISO
    nuclear membrane GO:0031965 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ipo5 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ipo5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ipo5 is involved
No pathways found





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