Gene description for Mapk3
Gene name mitogen activated protein kinase 3
Gene symbol Mapk3
Other names/aliases ERK1
ERT2
Erk-1
Esrk1
MAPK1
MNK1
Prkm3
p44
p44erk1
p44mapk
Species Rattus norvegicus
 Database cross references - Mapk3
ExoCarta ExoCarta_50689
Vesiclepedia VP_50689
Entrez Gene 50689
UniProt P21708  
 Mapk3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Mapk3
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IC
    protein binding GO:0005515 IPI
    phosphotyrosine binding GO:0001784 ISO
    protein kinase activity GO:0004672 ISO
    MAP kinase activity GO:0004707 ISO
    scaffold protein binding GO:0097110 IPI
    ATP binding GO:0005524 IDA
    phosphatase binding GO:0019902 ISO
Biological Process
    sensory perception of pain GO:0019233 ISO
    positive regulation of cyclase activity GO:0031281 ISO
    positive regulation of translation GO:0045727 IMP
    peptidyl-tyrosine autophosphorylation GO:0038083 ISO
    positive regulation of transcription, DNA-templated GO:0045893 IEP
    arachidonic acid metabolic process GO:0019369 IEP
    phosphorylation GO:0016310 ISO
    cellular response to DNA damage stimulus GO:0006974 ISO
    regulation of stress-activated MAPK cascade GO:0032872 TAS
    caveolin-mediated endocytosis GO:0072584 TAS
    DNA damage induced protein phosphorylation GO:0006975 ISO
    MAPK cascade GO:0000165 ISO
    trachea formation GO:0060440 ISO
    organ morphogenesis GO:0009887 ISO
    cellular response to mechanical stimulus GO:0071260 ISO
    transcription, DNA-templated GO:0006351 ISO
    intracellular signal transduction GO:0035556 TAS
    response to toxic substance GO:0009636 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of protein phosphorylation GO:0001934 ISO
    positive regulation of histone acetylation GO:0035066 ISO
    ERK1 and ERK2 cascade GO:0070371 ISO
    protein phosphorylation GO:0006468 TAS
    lung morphogenesis GO:0060425 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    apoptotic process GO:0006915 IEA
    regulation of Golgi inheritance GO:0090170 TAS
    regulation of early endosome to late endosome transport GO:2000641 TAS
    MAPK import into nucleus GO:0000189 IDA
    response to epidermal growth factor GO:0070849 ISS
    BMP signaling pathway GO:0030509 ISO
    interleukin-1-mediated signaling pathway GO:0070498 ISO
    peptidyl-serine phosphorylation GO:0018105 IMP
    response to lipopolysaccharide GO:0032496 ISO
    protein complex assembly GO:0006461 IMP
    negative regulation of apolipoprotein binding GO:2000657 ISO
    regulation of sequence-specific DNA binding transcription factor activity GO:0051090 ISO
    cartilage development GO:0051216 ISO
    response to exogenous dsRNA GO:0043330 ISO
    regulation of cytoskeleton organization GO:0051493 TAS
    positive regulation of histone phosphorylation GO:0033129 ISO
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISO
Subcellular Localization
    cytoskeleton GO:0005856 TAS
    intracellular GO:0005622 ISO
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 ISO
    late endosome GO:0005770 TAS
    protein complex GO:0043234 IDA
    nuclear envelope GO:0005635 ISO
    cytoplasm GO:0005737 ISO
    caveola GO:0005901 TAS
    focal adhesion GO:0005925 TAS
    Golgi apparatus GO:0005794 TAS
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 TAS
    early endosome GO:0005769 TAS
    pseudopodium GO:0031143 ISO
    microtubule cytoskeleton GO:0015630 ISO
    mitochondrion GO:0005739 TAS
 Experiment description of studies that identified Mapk3 in exosomes
1
Experiment ID 96
MISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Mapk3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mapk3 is involved
PathwayEvidenceSource
Activation of the AP-1 family of transcription factors IEA Reactome
Advanced glycosylation endproduct receptor signaling IEA Reactome
ERK/MAPK targets IEA Reactome
ERK/MAPK targets IEA Reactome
ERK1 activation IEA Reactome
ERK1 activation IEA Reactome
ERKs are inactivated IEA Reactome
ERKs are inactivated IEA Reactome
FCERI mediated MAPK activation IEA Reactome
Gastrin-CREB signalling pathway via PKC and MAPK IEA Reactome
Golgi Cisternae Pericentriolar Stack Reorganization IEA Reactome
Growth hormone receptor signaling IEA Reactome
ISG15 antiviral mechanism IEA Reactome
NCAM signaling for neurite out-growth IEA Reactome
Negative regulation of FGFR1 signaling IEA Reactome
Negative regulation of FGFR2 signaling IEA Reactome
Negative regulation of FGFR3 signaling IEA Reactome
Negative regulation of FGFR4 signaling IEA Reactome
Oncogene Induced Senescence IEA Reactome
Oxidative Stress Induced Senescence IEA Reactome
Regulation of actin dynamics for phagocytic cup formation IEA Reactome
Regulation of HSF1-mediated heat shock response IEA Reactome
RHO GTPases Activate WASPs and WAVEs IEA Reactome
RNA Polymerase I Promoter Opening IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) IEA Reactome
Signal attenuation IEA Reactome
Signal transduction by L1 IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Thrombin signalling through proteinase activated receptors (PARs) IEA Reactome





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