Gene description for PCNA
Gene name proliferating cell nuclear antigen
Gene symbol PCNA
Other names/aliases -
Species Bos taurus
 Database cross references - PCNA
ExoCarta ExoCarta_515499
Entrez Gene 515499
UniProt Q3ZBW4  
 PCNA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PCNA
Molecular Function
    dinucleotide insertion or deletion binding GO:0032139 IEA
    DNA polymerase binding GO:0070182 IEA
    purine-specific mismatch base pair DNA N-glycosylase activity GO:0000701 IEA
    receptor tyrosine kinase binding GO:0030971 IEA
    identical protein binding GO:0042802 IEA
    DNA polymerase processivity factor activity GO:0030337 IBA
    MutLalpha complex binding GO:0032405 IEA
Biological Process
    mismatch repair GO:0006298 IBA
    leading strand elongation GO:0006272 IBA
    positive regulation of deoxyribonuclease activity GO:0032077 ISS
    translesion synthesis GO:0019985 ISS
    regulation of DNA replication GO:0006275 IEA
    epithelial cell differentiation GO:0030855 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IBA
    centrosome GO:0005813 IEA
    PCNA-p21 complex GO:0070557 ISS
    nucleoplasm GO:0005654 IEA
    nuclear replication fork GO:0043596 IEA
    PCNA complex GO:0043626 IBA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PCNA in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PCNA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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