Gene description for PCNA
Gene name proliferating cell nuclear antigen
Gene symbol PCNA
Other names/aliases -
Species Bos taurus
 Database cross references - PCNA
ExoCarta ExoCarta_515499
Entrez Gene 515499
UniProt Q3ZBW4  
 PCNA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PCNA
Molecular Function
    dinucleotide insertion or deletion binding GO:0032139 IEA
    DNA polymerase binding GO:0070182 IEA
    purine-specific mismatch base pair DNA N-glycosylase activity GO:0000701 IEA
    receptor tyrosine kinase binding GO:0030971 IEA
    identical protein binding GO:0042802 IEA
    DNA polymerase processivity factor activity GO:0030337 IBA
    MutLalpha complex binding GO:0032405 IEA
Biological Process
    mismatch repair GO:0006298 IBA
    leading strand elongation GO:0006272 IBA
    positive regulation of deoxyribonuclease activity GO:0032077 ISS
    translesion synthesis GO:0019985 ISS
    regulation of DNA replication GO:0006275 IEA
    epithelial cell differentiation GO:0030855 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IBA
    centrosome GO:0005813 IEA
    PCNA-p21 complex GO:0070557 ISS
    nucleoplasm GO:0005654 IEA
    nuclear replication fork GO:0043596 IEA
    PCNA complex GO:0043626 IBA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PCNA in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PCNA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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