Gene description for ATP8A2
Gene name ATPase, aminophospholipid transporter, class I, type 8A, member 2
Gene symbol ATP8A2
Other names/aliases ATP
ATPIB
CAMRQ4
IB
ML-1
Species Homo sapiens
 Database cross references - ATP8A2
ExoCarta ExoCarta_51761
Entrez Gene 51761
HGNC 13533
MIM 605870
UniProt Q9NTI2  
 ATP8A2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ATP8A2
Molecular Function
    magnesium ion binding GO:0000287 IEA
    ATP binding GO:0005524 IEA
    phospholipid-translocating ATPase activity GO:0004012 IBA
Biological Process
    axonogenesis GO:0007409 IEA
    inner ear morphogenesis GO:0042472 IEA
    positive regulation of phospholipid translocation GO:0061092 IEA
    aging GO:0007568 IEA
    detection of light stimulus involved in visual perception GO:0050908 IEA
    positive regulation of multicellular organism growth GO:0040018 IEA
    negative regulation of cell proliferation GO:0008285 TAS
    phospholipid translocation GO:0045332 IBA
    positive regulation of neuron projection development GO:0010976 IEA
    neurofilament cytoskeleton organization GO:0060052 IEA
    retina layer formation GO:0010842 IEA
    neuron development GO:0048666 IBA
    response to auditory stimulus GO:0010996 IEA
    eating behavior GO:0042755 IEA
    metabolic process GO:0008152 IEA
    skin development GO:0043588 IEA
    involuntary skeletal muscle contraction GO:0003011 IEA
    neuromuscular process controlling posture GO:0050884 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endosome GO:0005768 IEA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    photoreceptor outer segment GO:0001750 IEA
 Experiment description of studies that identified ATP8A2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ATP8A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP8A2 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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