Gene description for PLCL1
Gene name phospholipase C-like 1
Gene symbol PLCL1
Other names/aliases PLCE
PLCL
PLDL1
PPP1R127
PRIP
Species Homo sapiens
 Database cross references - PLCL1
ExoCarta ExoCarta_5334
Vesiclepedia VP_5334
Entrez Gene 5334
HGNC 9063
MIM 600597
UniProt Q15111  
 PLCL1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PLCL1
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 IBA
    phospholipase C activity GO:0004629 TAS
Biological Process
    lipid metabolic process GO:0006629 IEA
    gamma-aminobutyric acid signaling pathway GO:0007214 IBA
    regulation of synaptic transmission, GABAergic GO:0032228 IBA
    intracellular signal transduction GO:0035556 IEA
    phosphatidylinositol metabolic process GO:0046488 IBA
    phosphatidylinositol-mediated signaling GO:0048015 IBA
    release of sequestered calcium ion into cytosol GO:0051209 IBA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PLCL1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLCL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLCL1 is involved
No pathways found





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