Gene description for Pdlim1
Gene name PDZ and LIM domain 1 (elfin)
Gene symbol Pdlim1
Other names/aliases CLP36
Clim1
mClim1
Species Mus musculus
 Database cross references - Pdlim1
ExoCarta ExoCarta_54132
Vesiclepedia VP_54132
Entrez Gene 54132
UniProt O70400  
 Pdlim1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdlim1
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    actin binding GO:0003779 IBA
    actin binding GO:0003779 IEA
    actin binding GO:0003779 ISO
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    muscle alpha-actinin binding GO:0051371 IBA
Biological Process
    response to hypoxia GO:0001666 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    heart development GO:0007507 IBA
    fibroblast migration GO:0010761 IEA
    fibroblast migration GO:0010761 ISO
    maintenance of cell polarity GO:0030011 IEA
    maintenance of cell polarity GO:0030011 ISO
    actin cytoskeleton organization GO:0030036 IBA
    actin cytoskeleton organization GO:0030036 ISO
    establishment or maintenance of actin cytoskeleton polarity GO:0030950 IEA
    establishment or maintenance of actin cytoskeleton polarity GO:0030950 ISO
    stress fiber assembly GO:0043149 IEA
    stress fiber assembly GO:0043149 ISO
    positive regulation of DNA-templated transcription GO:0045893 IEA
    muscle structure development GO:0061061 IBA
Subcellular Localization
    stress fiber GO:0001725 IBA
    stress fiber GO:0001725 IEA
    stress fiber GO:0001725 ISO
    transcription regulator complex GO:0005667 IDA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 ISO
    adherens junction GO:0005912 IBA
    actin cytoskeleton GO:0015629 ISO
    Z disc GO:0030018 IBA
    Z disc GO:0030018 IEA
    Z disc GO:0030018 ISO
    filamentous actin GO:0031941 IBA
 Experiment description of studies that identified Pdlim1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdlim1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Vim 22352
Co-fractionation Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Pdlim1 is involved
No pathways found





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