Gene description for CRLS1
Gene name cardiolipin synthase 1
Gene symbol CRLS1
Other names/aliases C20orf155
CLS
CLS1
GCD10
dJ967N21.6
Species Homo sapiens
 Database cross references - CRLS1
ExoCarta ExoCarta_54675
Entrez Gene 54675
HGNC 16148
MIM 608188
UniProt Q9UJA2  
 CRLS1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CRLS1
Molecular Function
    phosphotransferase activity, for other substituted phosphate groups GO:0016780 IEA
Biological Process
    glycerophospholipid biosynthetic process GO:0046474 TAS
    cardiolipin biosynthetic process GO:0032049 TAS
    phosphatidylglycerol acyl-chain remodeling GO:0036148 TAS
    small molecule metabolic process GO:0044281 TAS
    phospholipid metabolic process GO:0006644 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified CRLS1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CRLS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CRLS1 is involved
PathwayEvidenceSource
Acyl chain remodelling of PG TAS Reactome
Synthesis of CL TAS Reactome





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