Gene description for SYTL2
Gene name synaptotagmin-like 2
Gene symbol SYTL2
Other names/aliases CHR11SYT
EXO4
PPP1R151
SGA72M
SLP2
SLP2A
Species Homo sapiens
 Database cross references - SYTL2
ExoCarta ExoCarta_54843
Vesiclepedia VP_54843
Entrez Gene 54843
HGNC 15585
MIM 612880
UniProt Q9HCH5  
 SYTL2 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SYTL2
Molecular Function
    phosphatidylserine binding GO:0001786 IMP
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IMP
    phosphatase binding GO:0019902 IDA
    small GTPase binding GO:0031267 IEA
    neurexin family protein binding GO:0042043 IBA
    neurexin family protein binding GO:0042043 ISS
Biological Process
    intracellular protein transport GO:0006886 IEA
    exocytosis GO:0006887 IBA
    exocytosis GO:0006887 IDA
    vesicle docking involved in exocytosis GO:0006904 IDA
    vesicle-mediated transport GO:0016192 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 ISS
    melanosome GO:0042470 ISS
    exocytic vesicle GO:0070382 IBA
    exocytic vesicle GO:0070382 IDA
 Experiment description of studies that identified SYTL2 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SYTL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP1CA 5499
Two-hybrid Homo sapiens
2 FBXO25  
Biochemical Activity Homo sapiens
3 RPAP1  
Affinity Capture-MS Homo sapiens
4 MORN4  
Two-hybrid Homo sapiens
5 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
6 NCOA1  
Affinity Capture-MS Homo sapiens
7 YIF1A 10897
Two-hybrid Homo sapiens
8 RAB27A 5873
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
9 RAB27B 5874
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTERF1  
Reconstituted Complex Homo sapiens
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