Gene description for LARP6
Gene name La ribonucleoprotein domain family, member 6
Gene symbol LARP6
Other names/aliases ACHN
Species Homo sapiens
 Database cross references - LARP6
ExoCarta ExoCarta_55323
Vesiclepedia VP_55323
Entrez Gene 55323
HGNC 24012
MIM 611300
UniProt Q9BRS8  
 LARP6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LARP6
Molecular Function
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    myosin binding GO:0017022 IPI
    RNA stem-loop binding GO:0035613 IDA
    RNA stem-loop binding GO:0035613 IMP
    mRNA 5'-UTR binding GO:0048027 IDA
    mRNA 5'-UTR binding GO:0048027 IMP
    sequence-specific mRNA binding GO:1990825 IDA
Biological Process
    RNA processing GO:0006396 IEA
    regulation of translation GO:0006417 IEA
    positive regulation of collagen biosynthetic process GO:0032967 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IMP
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified LARP6 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LARP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 ITSN2 50618
Two-hybrid Homo sapiens
3 STRAP 11171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LARP6 is involved
No pathways found





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