Gene description for DNAH3
Gene name dynein, axonemal, heavy chain 3
Gene symbol DNAH3
Other names/aliases DLP3
DNAHC3B
HEL-36
Hsadhc3
dnahc3-b
Species Homo sapiens
 Database cross references - DNAH3
ExoCarta ExoCarta_55567
Entrez Gene 55567
HGNC 2949
MIM 603334
UniProt Q8TD57  
 DNAH3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DNAH3
Molecular Function
    microtubule motor activity GO:0003777 NAS
    ATP binding GO:0005524 IEA
Biological Process
    microtubule-based movement GO:0007018 IEA
    metabolic process GO:0008152 NAS
    cilium or flagellum-dependent cell motility GO:0001539 NAS
Subcellular Localization
    axonemal dynein complex GO:0005858 NAS
    microtubule GO:0005874 IEA
 Experiment description of studies that identified DNAH3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DNAH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH3 is involved
No pathways found





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