Gene description for Ykt6
Gene name YKT6 homolog (S. Cerevisiae)
Gene symbol Ykt6
Other names/aliases 0610042I15Rik
1810013M05Rik
AW105923
Species Mus musculus
 Database cross references - Ykt6
ExoCarta ExoCarta_56418
Vesiclepedia VP_56418
Entrez Gene 56418
UniProt Q9CQW1  
 Ykt6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ykt6
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    SNAP receptor activity GO:0005484 IEA
    SNAP receptor activity GO:0005484 ISO
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISO
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISS
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISO
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISS
    vesicle targeting GO:0006903 ISO
    vesicle targeting GO:0006903 ISS
    vesicle docking involved in exocytosis GO:0006904 ISO
    vesicle docking involved in exocytosis GO:0006904 ISS
    protein transport GO:0015031 IEA
    retrograde transport, endosome to Golgi GO:0042147 IEA
    retrograde transport, endosome to Golgi GO:0042147 ISO
    membrane fusion GO:0061025 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    endosome GO:0005768 IEA
    endosome GO:0005768 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cytoplasmic vesicle membrane GO:0030659 IEA
    SNARE complex GO:0031201 IEA
    SNARE complex GO:0031201 ISO
    neuronal cell body GO:0043025 IEA
    neuronal cell body GO:0043025 ISO
    apical dendrite GO:0097440 IEA
    apical dendrite GO:0097440 ISO
    basal dendrite GO:0097441 IEA
    basal dendrite GO:0097441 ISO
 Experiment description of studies that identified Ykt6 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ykt6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hspa9 15526
Co-fractionation Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Hnrnph1 59013
Co-fractionation Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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