Gene description for Mtor
Gene name	mechanistic target of rapamycin (serine/threonine kinase)
Gene symbol	Mtor
Other names/aliases	Frap1 RAFT1
Species	Rattus norvegicus
Database cross references - Mtor
ExoCarta	ExoCarta_56718
Vesiclepedia	VP_56718
Entrez Gene	56718
UniProt	P42346
Mtor identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Mtor

Molecular Function     inositol hexakisphosphate binding GO:0000822 ISO     inositol hexakisphosphate binding GO:0000822 ISS     RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001002 IEA     RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001002 ISO     RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0001003 IEA     RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0001003 ISO     RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006 IEA     RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006 ISO     TFIIIC-class transcription factor complex binding GO:0001156 IEA     TFIIIC-class transcription factor complex binding GO:0001156 ISO     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 IEA     protein serine/threonine kinase activity GO:0004674 IMP     protein serine/threonine kinase activity GO:0004674 ISO     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein tyrosine kinase activity GO:0004713 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IPI     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     ribosome binding GO:0043022 IEA     ribosome binding GO:0043022 ISO     ribosome binding GO:0043022 ISS     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     protein-containing complex binding GO:0044877 IEA     metal ion binding GO:0046872 IEA     phosphoprotein binding GO:0051219 IEA     phosphoprotein binding GO:0051219 ISO     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     regulation of cell growth GO:0001558 IEA     regulation of cell growth GO:0001558 ISO     regulation of protein phosphorylation GO:0001932 ISO     negative regulation of protein phosphorylation GO:0001933 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of endothelial cell proliferation GO:0001938 IMP     T-helper 1 cell lineage commitment GO:0002296 IEA     T-helper 1 cell lineage commitment GO:0002296 ISO     heart morphogenesis GO:0003007 IEA     heart morphogenesis GO:0003007 ISO     heart valve morphogenesis GO:0003179 IEA     heart valve morphogenesis GO:0003179 ISO     regulation of glycogen biosynthetic process GO:0005979 IDA     regulation of glycogen biosynthetic process GO:0005979 IMP     regulation of carbohydrate metabolic process GO:0006109 IDA     regulation of carbohydrate metabolic process GO:0006109 IMP     energy reserve metabolic process GO:0006112 IEA     energy reserve metabolic process GO:0006112 ISO     'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA     'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 ISO     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 IMP     inflammatory response GO:0006954 IEA     inflammatory response GO:0006954 ISO     lysosome organization GO:0007040 IEA     germ cell development GO:0007281 IEA     germ cell development GO:0007281 ISO     long-term memory GO:0007616 IMP     regulation of cell size GO:0008361 ISO     visual learning GO:0008542 IMP     cellular response to starvation GO:0009267 ISO     response to heat GO:0009408 IEA     response to heat GO:0009408 ISO     post-embryonic development GO:0009791 IEA     post-embryonic development GO:0009791 ISO     regulation of autophagy GO:0010506 ISO     regulation of autophagy GO:0010506 ISS     negative regulation of autophagy GO:0010507 IEA     negative regulation of autophagy GO:0010507 IMP     negative regulation of autophagy GO:0010507 ISO     negative regulation of autophagy GO:0010507 ISS     positive regulation of lamellipodium assembly GO:0010592 IEA     positive regulation of lamellipodium assembly GO:0010592 ISO     positive regulation of epithelial to mesenchymal transition GO:0010718 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     positive regulation of myotube differentiation GO:0010831 IEA     positive regulation of myotube differentiation GO:0010831 ISO     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of neuron maturation GO:0014042 IMP     negative regulation of muscle atrophy GO:0014736 IMP     response to activity GO:0014823 IEP     macroautophagy GO:0016236 IEA     macroautophagy GO:0016236 ISO     negative regulation of macroautophagy GO:0016242 IBA     negative regulation of macroautophagy GO:0016242 IEA     negative regulation of macroautophagy GO:0016242 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     peptidyl-threonine phosphorylation GO:0018107 ISO     neuronal action potential GO:0019228 IEA     neuronal action potential GO:0019228 ISO     spinal cord development GO:0021510 IDA     cell projection organization GO:0030030 IGI     cell projection organization GO:0030030 ISO     positive regulation of actin filament polymerization GO:0030838 IEA     positive regulation of actin filament polymerization GO:0030838 ISO     negative regulation of protein ubiquitination GO:0031397 IMP     ruffle organization GO:0031529 IEA     ruffle organization GO:0031529 ISO     regulation of myelination GO:0031641 IEA     regulation of myelination GO:0031641 ISO     protein destabilization GO:0031648 IEA     protein destabilization GO:0031648 ISO     protein destabilization GO:0031648 ISS     response to nutrient levels GO:0031667 ISO     response to nutrient levels GO:0031667 ISS     cellular response to nutrient levels GO:0031669 ISO     cellular response to nutrient levels GO:0031669 ISS     cellular response to nutrient GO:0031670 ISO     TOR signaling GO:0031929 ISO     TOR signaling GO:0031929 ISS     regulation of fatty acid beta-oxidation GO:0031998 IDA     regulation of fatty acid beta-oxidation GO:0031998 IMP     regulation of response to food GO:0032095 IDA     regulation of response to food GO:0032095 IMP     response to insulin GO:0032868 ISO     cellular response to insulin stimulus GO:0032869 IEA     cellular response to insulin stimulus GO:0032869 ISO     cellular response to insulin stimulus GO:0032869 ISS     regulation of actin cytoskeleton organization GO:0032956 ISO     calcineurin-NFAT signaling cascade GO:0033173 IEA     calcineurin-NFAT signaling cascade GO:0033173 ISO     cellular response to amino acid starvation GO:0034198 ISO     cellular response to amino acid starvation GO:0034198 ISS     social behavior GO:0035176 IMP     multicellular organism growth GO:0035264 IEA     multicellular organism growth GO:0035264 ISO     TORC1 signaling GO:0038202 IBA     TORC1 signaling GO:0038202 IEA     TORC1 signaling GO:0038202 ISO     TORC1 signaling GO:0038202 ISS     TORC2 signaling GO:0038203 ISO     TORC2 signaling GO:0038203 ISS     response to cocaine GO:0042220 IMP     regulation of circadian rhythm GO:0042752 ISO     regulation of circadian rhythm GO:0042752 ISS     response to amino acid GO:0043200 ISO     response to amino acid GO:0043200 ISO     positive regulation of neuron apoptotic process GO:0043525 IMP     regulation of carbohydrate utilization GO:0043610 IDA     regulation of carbohydrate utilization GO:0043610 IMP     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     regulation of osteoclast differentiation GO:0045670 IEA     regulation of osteoclast differentiation GO:0045670 ISO     regulation of osteoclast differentiation GO:0045670 ISS     positive regulation of translation GO:0045727 IMP     positive regulation of translation GO:0045727 ISO     negative regulation of cell size GO:0045792 IEA     negative regulation of cell size GO:0045792 IMP     negative regulation of cell size GO:0045792 ISO     regulation of protein kinase activity GO:0045859 ISO     positive regulation of transcription by RNA polymerase III GO:0045945 IEA     positive regulation of transcription by RNA polymerase III GO:0045945 ISO     positive regulation of translational initiation GO:0045948 IEA     positive regulation of translational initiation GO:0045948 ISO     protein autophosphorylation GO:0046777 IMP     positive regulation of lipid biosynthetic process GO:0046889 IEA     positive regulation of lipid biosynthetic process GO:0046889 ISO     positive regulation of lipid biosynthetic process GO:0046889 ISS     mRNA stabilization GO:0048255 IMP     behavioral response to pain GO:0048266 IEA     behavioral response to pain GO:0048266 ISO     rhythmic process GO:0048511 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     oligodendrocyte differentiation GO:0048709 IEA     oligodendrocyte differentiation GO:0048709 ISO     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     positive regulation of oligodendrocyte differentiation GO:0048714 IMP     positive regulation of oligodendrocyte differentiation GO:0048714 ISO     cardiac muscle tissue development GO:0048738 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of neurogenesis GO:0050769 IMP     voluntary musculoskeletal movement GO:0050882 IEA     voluntary musculoskeletal movement GO:0050882 ISO     regulation of cellular component organization GO:0051128 IEA     positive regulation of protein metabolic process GO:0051247 IEA     positive regulation of stress fiber assembly GO:0051496 IEA     positive regulation of stress fiber assembly GO:0051496 ISO     positive regulation of keratinocyte migration GO:0051549 IEA     positive regulation of keratinocyte migration GO:0051549 ISO     nucleus localization GO:0051647 IEA     regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IEA     regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     cardiac cell development GO:0055006 ISO     cardiac muscle cell development GO:0055013 IEA     cardiac muscle cell development GO:0055013 ISO     cardiac muscle contraction GO:0060048 IEA     cardiac muscle contraction GO:0060048 ISO     maternal process involved in female pregnancy GO:0060135 IDA     positive regulation of glial cell proliferation GO:0060252 IMP     positive regulation of dendritic spine development GO:0060999 IMP     positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 IMP     cellular response to methionine GO:0061431 IEA     cellular response to methionine GO:0061431 ISO     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IEA     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISO     cellular response to amino acid stimulus GO:0071230 ISO     cellular response to L-leucine GO:0071233 IEA     cellular response to L-leucine GO:0071233 ISO     cellular response to hypoxia GO:0071456 IEA     cellular response to hypoxia GO:0071456 ISO     cellular response to hypoxia GO:0071456 ISS     regulation of brown fat cell differentiation GO:0090335 IMP     regulation of membrane permeability GO:0090559 IEA     regulation of membrane permeability GO:0090559 ISO     regulation of translation at synapse, modulating synaptic transmission GO:0099547 EXP     regulation of translation at synapse, modulating synaptic transmission GO:0099547 IDA     regulation of translation at synapse, modulating synaptic transmission GO:0099547 IEP     regulation of translation at synapse, modulating synaptic transmission GO:0099547 IMP     negative regulation of protein localization to nucleus GO:1900181 IEA     negative regulation of protein localization to nucleus GO:1900181 ISO     negative regulation of protein localization to nucleus GO:1900181 ISS     positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 IEA     positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 ISO     positive regulation of wound healing, spreading of epidermal cells GO:1903691 IEA     positive regulation of wound healing, spreading of epidermal cells GO:1903691 ISO     positive regulation of eating behavior GO:1904000 IMP     positive regulation of epithelial cell apoptotic process GO:1904037 IMP     positive regulation of cholangiocyte proliferation GO:1904056 IMP     regulation of locomotor rhythm GO:1904059 IEA     regulation of locomotor rhythm GO:1904059 ISO     regulation of locomotor rhythm GO:1904059 ISS     negative regulation of cholangiocyte apoptotic process GO:1904193 IMP     positive regulation of granulosa cell proliferation GO:1904197 IMP     positive regulation of skeletal muscle hypertrophy GO:1904206 IMP     negative regulation of iodide transmembrane transport GO:1904213 IMP     regulation of lysosome organization GO:1905671 ISO     regulation of lysosome organization GO:1905671 ISS     negative regulation of lysosome organization GO:1905672 IEA     negative regulation of lysosome organization GO:1905672 ISO     negative regulation of lysosome organization GO:1905672 ISS     cellular response to leucine starvation GO:1990253 IEA     cellular response to leucine starvation GO:1990253 ISO     positive regulation of cellular senescence GO:2000774 IMP     regulation of autophagosome assembly GO:2000785 IEA     regulation of autophagosome assembly GO:2000785 ISO Subcellular Localization     Golgi membrane GO:0000139 IEA     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nuclear envelope GO:0005635 IEA     nuclear envelope GO:0005635 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     mitochondrial outer membrane GO:0005741 IEA     lysosome GO:0005764 ISO     lysosome GO:0005764 ISS     lysosomal membrane GO:0005765 IEA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     endoplasmic reticulum membrane GO:0005789 IEA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     endomembrane system GO:0012505 ISO     membrane GO:0016020 ISO     PML body GO:0016605 IEA     PML body GO:0016605 ISO     PML body GO:0016605 ISS     dendrite GO:0030425 IDA     dendrite GO:0030425 IEA     dendrite GO:0030425 ISO     TORC1 complex GO:0031931 IBA     TORC1 complex GO:0031931 IDA     TORC1 complex GO:0031931 IEA     TORC1 complex GO:0031931 ISO     TORC2 complex GO:0031932 IBA     TORC2 complex GO:0031932 IEA     TORC2 complex GO:0031932 ISO     TORC2 complex GO:0031932 ISS     protein-containing complex GO:0032991 IDA     neuronal cell body GO:0043025 IDA     phagocytic vesicle GO:0045335 IEA     phagocytic vesicle GO:0045335 ISO     phagocytic vesicle GO:0045335 ISS     glutamatergic synapse GO:0098978 IDA     postsynaptic cytosol GO:0099524 IDA