Gene description for Mtor
Gene name	mechanistic target of rapamycin (serine/threonine kinase)
Gene symbol	Mtor
Other names/aliases	Frap1 RAFT1
Species	Rattus norvegicus
Database cross references - Mtor
ExoCarta	ExoCarta_56718
Entrez Gene	56718
UniProt	P42346
Mtor identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Mtor

Molecular Function     RNA polymerase III type 1 promoter DNA binding GO:0001030 ISO     RNA polymerase III type 2 promoter DNA binding GO:0001031 ISO     TFIIIC-class transcription factor binding GO:0001156 ISO     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     phosphoprotein binding GO:0051219 ISO     drug binding GO:0008144 IEA     protein dimerization activity GO:0046983 IBA     ATP binding GO:0005524 IEA     RNA polymerase III type 3 promoter DNA binding GO:0001032 ISO     kinase activity GO:0016301 ISO     protein serine/threonine kinase activity GO:0004674 ISO     ribosome binding GO:0043022 ISO     protein domain specific binding GO:0019904 IPI Biological Process     regulation of glycogen biosynthetic process GO:0005979 IMP     positive regulation of stress fiber assembly GO:0051496 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     germ cell development GO:0007281 ISO     negative regulation of NFAT protein import into nucleus GO:0051534 ISO     TOR signaling GO:0031929 ISO     negative regulation of macroautophagy GO:0016242 ISO     positive regulation of granulosa cell proliferation GO:1904197 IMP     positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 IMP     regulation of response to food GO:0032095 IMP     response to insulin GO:0032868 ISO     regulation of protein kinase activity GO:0045859 ISO     phosphorylation GO:0016310 ISO     protein autophosphorylation GO:0046777 ISO     positive regulation of dendritic spine development GO:0060999 IMP     negative regulation of cell size GO:0045792 ISO     negative regulation of iodide transmembrane transport GO:1904213 IMP     cell projection organization GO:0030030 ISO     regulation of GTPase activity GO:0043087 ISO     cell growth GO:0016049 ISO     positive regulation of gene expression GO:0010628 ISO     positive regulation of neurogenesis GO:0050769 IMP     positive regulation of lamellipodium assembly GO:0010592 ISO     cellular response to hypoxia GO:0071456 ISS     positive regulation of protein kinase B signaling GO:0051897 IMP     positive regulation of neuron death GO:1901216 IMP     regulation of brown fat cell differentiation GO:0090335 IMP     mRNA stabilization GO:0048255 IMP     positive regulation of transcription from RNA polymerase III promoter GO:0045945 ISO     wound healing GO:0042060 IEP     positive regulation of actin filament polymerization GO:0030838 ISO     positive regulation of eating behavior GO:1904000 IMP     long-term memory GO:0007616 IMP     regulation of myelination GO:0031641 ISO     regulation of carbohydrate metabolic process GO:0006109 IMP     social behavior GO:0035176 IMP     positive regulation of oligodendrocyte differentiation GO:0048714 IMP     positive regulation of endothelial cell proliferation GO:0001938 IMP     visual learning GO:0008542 IMP     cellular response to nutrient levels GO:0031669 ISS     positive regulation of cholangiocyte proliferation GO:1904056 IMP     response to amino acid GO:0043200 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     positive regulation of skeletal muscle hypertrophy GO:1904206 IMP     response to morphine GO:0043278 IMP     positive regulation of myotube differentiation GO:0010831 ISO     brain development GO:0007420 IEP     peptidyl-threonine phosphorylation GO:0018107 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of neuron maturation GO:0014042 IMP     spinal cord development GO:0021510 IDA     cell aging GO:0007569 IEP     regulation of carbohydrate utilization GO:0043610 IMP     regulation of actin cytoskeleton organization GO:0032956 ISO     positive regulation of lipid biosynthetic process GO:0046889 ISS     double-strand break repair via homologous recombination GO:0000724 IBA     response to cocaine GO:0042220 IMP     negative regulation of protein ubiquitination GO:0031397 IMP     positive regulation of translation GO:0045727 ISO     negative regulation of cholangiocyte apoptotic process GO:1904193 IMP     ruffle organization GO:0031529 ISO     regulation of osteoclast differentiation GO:0045670 ISS     negative regulation of protein phosphorylation GO:0001933 IMP     regulation of fatty acid beta-oxidation GO:0031998 IMP     maternal process involved in female pregnancy GO:0060135 IDA     positive regulation of cell death GO:0010942 IMP     negative regulation of muscle atrophy GO:0014736 IMP     positive regulation of sensory perception of pain GO:1904058 IMP     protein phosphorylation GO:0006468 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of autophagy GO:0010507 ISS     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     positive regulation of glial cell proliferation GO:0060252 IMP Subcellular Localization     nucleus GO:0005634 ISO     lysosomal membrane GO:0005765 ISO     cytosol GO:0005829 ISO     lysosome GO:0005764 ISS     TORC1 complex GO:0031931 ISO     PML body GO:0016605 ISS     Golgi membrane GO:0000139 IEA     neuronal cell body GO:0043025 IDA     endomembrane system GO:0012505 ISO     TORC2 complex GO:0031932 ISO     dendrite GO:0030425 ISO     mitochondrial outer membrane GO:0005741 IEA     macromolecular complex GO:0032991 IDA     membrane GO:0016020 ISO     endoplasmic reticulum membrane GO:0005789 IEA     cytoplasm GO:0005737 ISO