Gene description for Aldh9a1
Gene name aldehyde dehydrogenase 9, subfamily A1
Gene symbol Aldh9a1
Other names/aliases AA139417
Abaldh
ESTM40
TMABA-DH
Tmabadh
Species Mus musculus
 Database cross references - Aldh9a1
ExoCarta ExoCarta_56752
Vesiclepedia VP_56752
Entrez Gene 56752
UniProt Q9JLJ2  
 Aldh9a1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aldh9a1
Molecular Function
    aldehyde dehydrogenase (NAD+) activity GO:0004029 ISO
    aldehyde dehydrogenase (NAD+) activity GO:0004029 ISS
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IDA
    formaldehyde dehydrogenase (NAD+) activity GO:0018467 ISO
    formaldehyde dehydrogenase (NAD+) activity GO:0018467 ISS
    aminobutyraldehyde dehydrogenase (NAD+) activity GO:0019145 IBA
    aminobutyraldehyde dehydrogenase (NAD+) activity GO:0019145 ISO
    aminobutyraldehyde dehydrogenase (NAD+) activity GO:0019145 ISS
    small molecule binding GO:0036094 ISO
    identical protein binding GO:0042802 ISO
    amine binding GO:0043176 ISO
    4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105 IBA
    4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105 IDA
    4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105 ISO
    4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105 ISS
    NAD binding GO:0051287 ISO
Biological Process
    aldehyde metabolic process GO:0006081 ISO
    aldehyde metabolic process GO:0006081 ISS
    carnitine metabolic process GO:0009437 IDA
    carnitine biosynthetic process GO:0045329 IDA
    carnitine biosynthetic process GO:0045329 IEA
    protein homotetramerization GO:0051289 ISO
    protein homotetramerization GO:0051289 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 HDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Aldh9a1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldh9a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ankfy1 11736
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Aldh9a1 is involved
PathwayEvidenceSource
Carnitine synthesis IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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