Gene description for HCN3
Gene name hyperpolarization activated cyclic nucleotide gated potassium channel 3
Gene symbol HCN3
Other names/aliases -
Species Homo sapiens
 Database cross references - HCN3
ExoCarta ExoCarta_57657
Vesiclepedia VP_57657
Entrez Gene 57657
HGNC 19183
MIM 609973
UniProt Q9P1Z3  
 HCN3 identified in sEVs derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for HCN3
Molecular Function
    voltage-gated sodium channel activity GO:0005248 IDA
    voltage-gated sodium channel activity GO:0005248 IMP
    voltage-gated potassium channel activity GO:0005249 IBA
    voltage-gated potassium channel activity GO:0005249 IDA
    voltage-gated potassium channel activity GO:0005249 IMP
    protein binding GO:0005515 IPI
    cAMP binding GO:0030552 IEA
Biological Process
    regulation of membrane depolarization GO:0003254 IBA
    sodium ion transmembrane transport GO:0035725 IBA
    sodium ion transmembrane transport GO:0035725 IDA
    sodium ion transmembrane transport GO:0035725 IMP
    regulation of membrane potential GO:0042391 IMP
    cellular response to cAMP GO:0071320 IDA
    potassium ion transmembrane transport GO:0071805 IBA
    potassium ion transmembrane transport GO:0071805 IDA
    potassium ion transmembrane transport GO:0071805 IMP
    cellular response to dopamine GO:1903351 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IBA
    dendrite GO:0030425 IBA
    neuronal cell body GO:0043025 IEA
    cone cell pedicle GO:0044316 IEA
    HCN channel complex GO:0098855 IBA
 Experiment description of studies that identified HCN3 in sEVs
1
Experiment ID 44
MISEV standards
IEM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for HCN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TTYH1  
Affinity Capture-MS Homo sapiens
2 HCN4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
4 HCN1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which HCN3 is involved
PathwayEvidenceSource
HCN channels TAS Reactome
Neuronal System TAS Reactome
Potassium Channels TAS Reactome





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