Gene description for HCN3
Gene name hyperpolarization activated cyclic nucleotide gated potassium channel 3
Gene symbol HCN3
Other names/aliases -
Species Homo sapiens
 Database cross references - HCN3
ExoCarta ExoCarta_57657
Entrez Gene 57657
HGNC 19183
MIM 609973
UniProt Q9P1Z3  
 HCN3 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for HCN3
Molecular Function
    cAMP binding GO:0030552 IEA
    voltage-gated potassium channel activity GO:0005249 IMP
    voltage-gated sodium channel activity GO:0005248 IMP
Biological Process
    synaptic transmission GO:0007268 TAS
    regulation of membrane potential GO:0042391 IMP
    sodium ion transmembrane transport GO:0035725 IMP
    potassium ion transmembrane transport GO:0071805 IMP
    cellular response to cAMP GO:0071320 IDA
    regulation of ion transmembrane transport GO:0034765 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified HCN3 in exosomes
1
Experiment ID 44
ISEV standards
IEM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for HCN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HCN4  
Affinity Capture-Western Homo sapiens
2 HCN1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which HCN3 is involved
PathwayEvidenceSource
HCN channels TAS Reactome





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