Gene description for RARRES2
Gene name retinoic acid receptor responder (tazarotene induced) 2
Gene symbol RARRES2
Other names/aliases HP10433
TIG2
Species Homo sapiens
 Database cross references - RARRES2
ExoCarta ExoCarta_5919
Vesiclepedia VP_5919
Entrez Gene 5919
HGNC 9868
MIM 601973
UniProt Q99969  
 RARRES2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RARRES2
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
Biological Process
    retinoid metabolic process GO:0001523 IDA
    positive regulation of protein phosphorylation GO:0001934 IDA
    chemotaxis GO:0006935 IEA
    inflammatory response GO:0006954 IEA
    insulin receptor signaling pathway GO:0008286 IDA
    positive regulation of macrophage chemotaxis GO:0010759 IMP
    antifungal humoral response GO:0019732 IMP
    cell differentiation GO:0030154 IEA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IMP
    positive regulation of fat cell differentiation GO:0045600 ISS
    embryonic digestive tract development GO:0048566 IMP
    defense response to Gram-negative bacterium GO:0050829 IMP
    defense response to Gram-positive bacterium GO:0050830 IMP
    positive regulation of chemotaxis GO:0050921 IBA
    positive regulation of chemotaxis GO:0050921 ISS
    regulation of lipid catabolic process GO:0050994 IBA
    regulation of lipid catabolic process GO:0050994 ISS
    antifungal innate immune response GO:0061760 IMP
Subcellular Localization
    extracellular region GO:0005576 ISS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular matrix GO:0031012 IBA
    platelet dense granule lumen GO:0031089 TAS
    collagen-containing extracellular matrix GO:0062023 IDA
 Experiment description of studies that identified RARRES2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RARRES2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBB8 347688
Affinity Capture-MS Homo sapiens
2 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
3 CDKN2D  
Affinity Capture-MS Homo sapiens
4 TNFSF9  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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