Gene description for RP1
Gene name retinitis pigmentosa 1 (autosomal dominant)
Gene symbol RP1
Other names/aliases DCDC4A
ORP1
Species Homo sapiens
 Database cross references - RP1
ExoCarta ExoCarta_6101
Entrez Gene 6101
HGNC 10263
MIM 603937
UniProt P56715  
 RP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RP1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 ISS
Biological Process
    axoneme assembly GO:0035082 ISS
    retina development in camera-type eye GO:0060041 IBA
    photoreceptor cell outer segment organization GO:0035845 ISS
    phototransduction, visible light GO:0007603 TAS
    cellular response to light stimulus GO:0071482 IEA
    retinal rod cell development GO:0046548 ISS
    visual perception GO:0007601 IEA
    retinal cone cell development GO:0046549 ISS
    photoreceptor cell maintenance GO:0045494 ISS
    photoreceptor cell development GO:0042461 ISS
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    photoreceptor inner segment GO:0001917 IDA
    photoreceptor connecting cilium GO:0032391 IDA
    axoneme GO:0005930 IBA
    microtubule GO:0005874 IEA
    photoreceptor outer segment GO:0001750 ISS
    microtubule associated complex GO:0005875 ISS
 Experiment description of studies that identified RP1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APC  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which RP1 is involved
No pathways found





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