Gene description for DMRTA1
Gene name DMRT-like family A1
Gene symbol DMRTA1
Other names/aliases DMO
DMRT4
Species Homo sapiens
 Database cross references - DMRTA1
ExoCarta ExoCarta_63951
Entrez Gene 63951
HGNC 13826
MIM 614803
UniProt Q5VZB9  
 DMRTA1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DMRTA1
Molecular Function
    core promoter proximal region sequence-specific DNA binding GO:0000987 IBA
    metal ion binding GO:0046872 IEA
    protein homodimerization activity GO:0042803 IBA
    sequence-specific DNA binding transcription factor activity GO:0003700 IBA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    male mating behavior GO:0060179 IEA
    ovarian follicle development GO:0001541 IEA
    sex differentiation GO:0007548 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified DMRTA1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DMRTA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DMRTA1 is involved
No pathways found





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