Gene description for ADGRL4
Gene name adhesion G protein-coupled receptor L4
Gene symbol ADGRL4
Other names/aliases ELTD1
ETL
KPG_003
Species Homo sapiens
 Database cross references - ADGRL4
ExoCarta ExoCarta_64123
Vesiclepedia VP_64123
Entrez Gene 64123
HGNC 20822
UniProt Q9HBW9  
 ADGRL4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ADGRL4
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    calcium ion binding GO:0005509 IEA
Biological Process
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 TAS
    cytoplasmic vesicle GO:0031410 ISS
 Experiment description of studies that identified ADGRL4 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADGRL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADGRL4 64123
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ADGRL4 is involved
No pathways found





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