Gene description for Fgf23
Gene name fibroblast growth factor 23
Gene symbol Fgf23
Other names/aliases -
Species Mus musculus
 Database cross references - Fgf23
ExoCarta ExoCarta_64654
Entrez Gene 64654
UniProt Q9EPC2  
 Fgf23 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fgf23
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    fibroblast growth factor receptor binding GO:0005104 IPI
    type 1 fibroblast growth factor receptor binding GO:0005105 IPI
Biological Process
    fibroblast growth factor receptor signaling pathway GO:0008543 IPI
    negative regulation of hormone secretion GO:0046888 ISO
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    vitamin D catabolic process GO:0042369 ISO
    cellular phosphate ion homeostasis GO:0030643 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of osteoblast differentiation GO:0045668 ISO
    regulation of phosphate transport GO:0010966 ISO
    negative regulation of bone mineralization GO:0030502 ISO
    regulation of bone mineralization GO:0030500 IMP
    cell differentiation GO:0030154 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IGI
    positive regulation of vitamin D 24-hydroxylase activity GO:0010980 ISO
    phosphate ion homeostasis GO:0055062 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    cell GO:0005623 IMP
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Fgf23 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Fgf23
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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