Gene description for Fgfr1
Gene name	fibroblast growth factor receptor 1
Gene symbol	Fgfr1
Other names/aliases	AW208770 Eask FLG Fgfr-1 Flt-2 Hspy MFR bFGF-R-1 c-fgr
Species	Mus musculus
Database cross references - Fgfr1
ExoCarta	ExoCarta_14182
Vesiclepedia	VP_14182
Entrez Gene	14182
UniProt	P16092
Fgfr1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Fgfr1

Molecular Function     protein tyrosine kinase activity GO:0004713 ISO     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IBA     fibroblast growth factor receptor activity GO:0005007 IDA     fibroblast growth factor receptor activity GO:0005007 ISO     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     signaling receptor binding GO:0005102 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     heparin binding GO:0008201 ISO     heparin binding GO:0008201 ISS     boss receptor activity GO:0008288 IEA     fibroblast growth factor binding GO:0017134 IBA     fibroblast growth factor binding GO:0017134 IDA     fibroblast growth factor binding GO:0017134 IPI     fibroblast growth factor binding GO:0017134 ISO     fibroblast growth factor binding GO:0017134 ISS     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     SH2 domain binding GO:0042169 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein-containing complex binding GO:0044877 ISO     cell adhesion molecule binding GO:0050839 ISO     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     receptor-receptor interaction GO:0090722 IEA     receptor-receptor interaction GO:0090722 ISO     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     angiogenesis GO:0001525 IGI     ureteric bud development GO:0001657 IGI     in utero embryonic development GO:0001701 IGI     organ induction GO:0001759 IMP     epithelial to mesenchymal transition GO:0001837 IEA     epithelial to mesenchymal transition GO:0001837 ISO     positive regulation of mesenchymal cell proliferation GO:0002053 IGI     positive regulation of mesenchymal cell proliferation GO:0002053 IMP     positive regulation of mesenchymal cell proliferation GO:0002053 ISO     chondrocyte differentiation GO:0002062 IGI     chromatin remodeling GO:0006338 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     brain development GO:0007420 IMP     salivary gland morphogenesis GO:0007435 IMP     sensory perception of sound GO:0007605 IMP     cell population proliferation GO:0008283 IGI     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 TAS     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IGI     fibroblast growth factor receptor signaling pathway GO:0008543 ISO     fibroblast growth factor receptor signaling pathway GO:0008543 ISO     mesenchymal cell proliferation GO:0010463 IGI     mesenchymal cell proliferation GO:0010463 IMP     gene expression GO:0010467 IDA     gene expression GO:0010467 IMP     regulation of gene expression GO:0010468 IMP     negative regulation of gene expression GO:0010629 IGI     negative regulation of gene expression GO:0010629 IMP     positive regulation of fibroblast migration GO:0010763 ISO     regulation of phosphate transport GO:0010966 IGI     positive regulation of neuron projection development GO:0010976 IGI     positive regulation of neuron projection development GO:0010976 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISO     stem cell population maintenance GO:0019827 ISO     orbitofrontal cortex development GO:0021769 IMP     postnatal olfactory bulb interneuron migration GO:0021827 ISO     ventricular zone neuroblast division GO:0021847 IMP     central nervous system neuron development GO:0021954 ISO     tangential migration from the subventricular zone to the olfactory bulb GO:0022028 ISO     cell projection assembly GO:0030031 IDA     cell projection assembly GO:0030031 IMP     lung development GO:0030324 IGI     lung development GO:0030324 IMP     embryonic limb morphogenesis GO:0030326 IMP     midbrain development GO:0030901 IGI     midbrain development GO:0030901 IMP     neuron projection development GO:0031175 IGI     neuron projection development GO:0031175 ISO     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IMP     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     regulation of cell population proliferation GO:0042127 ISO     inner ear morphogenesis GO:0042472 IMP     outer ear morphogenesis GO:0042473 IMP     middle ear morphogenesis GO:0042474 IMP     positive regulation of MAP kinase activity GO:0043406 ISO     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     ear development GO:0043583 IMP     cellular response to fibroblast growth factor stimulus GO:0044344 ISO     positive regulation of cell differentiation GO:0045597 IBA     positive regulation of neuron differentiation GO:0045666 ISO     positive regulation of neuron differentiation GO:0045666 ISS     negative regulation of osteoblast differentiation GO:0045668 ISO     positive regulation of cell cycle GO:0045787 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 ISS     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     paraxial mesoderm development GO:0048339 IGI     regulation of lateral mesodermal cell fate specification GO:0048378 IGI     cell maturation GO:0048469 IMP     blood vessel morphogenesis GO:0048514 IMP     generation of neurons GO:0048699 IMP     mesenchymal cell differentiation GO:0048762 IGI     stem cell differentiation GO:0048863 IGI     regulation of epithelial cell proliferation GO:0050678 IMP     regulation of phosphorus metabolic process GO:0051174 IGI     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     calcium ion homeostasis GO:0055074 IGI     cardiac muscle cell proliferation GO:0060038 IGI     positive regulation of cardiac muscle cell proliferation GO:0060045 IGI     positive regulation of cardiac muscle cell proliferation GO:0060045 ISO     auditory receptor cell development GO:0060117 IMP     branching involved in salivary gland morphogenesis GO:0060445 IMP     lung-associated mesenchyme development GO:0060484 IGI     regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IDA     vasculogenesis involved in coronary vascular morphogenesis GO:0060979 TAS     vitamin D3 metabolic process GO:0070640 IGI     diphosphate metabolic process GO:0071344 IDA     diphosphate metabolic process GO:0071344 IMP     cementum mineralization GO:0071529 IDA     cementum mineralization GO:0071529 IMP     stem cell proliferation GO:0072089 IGI     stem cell proliferation GO:0072089 IMP     regulation of stem cell proliferation GO:0072091 ISO     positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IGI     negative regulation of fibroblast growth factor production GO:0090272 IGI     regulation of postsynaptic density assembly GO:0099151 IDA     regulation of postsynaptic density assembly GO:0099151 IMP     positive regulation of mitotic cell cycle DNA replication GO:1903465 IDA     response to sodium phosphate GO:1904383 IDA     response to sodium phosphate GO:1904383 IGI     positive regulation of vascular endothelial cell proliferation GO:1905564 IEA     positive regulation of vascular endothelial cell proliferation GO:1905564 ISO     positive regulation of hepatic stellate cell activation GO:2000491 ISO     positive regulation of stem cell proliferation GO:2000648 IGI     positive regulation of stem cell proliferation GO:2000648 IMP     positive regulation of parathyroid hormone secretion GO:2000830 IGI     positive regulation of endothelial cell chemotaxis GO:2001028 IEA     positive regulation of endothelial cell chemotaxis GO:2001028 ISO     regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IMP Subcellular Localization     nucleus GO:0005634 IEA     cytosol GO:0005829 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IPI     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     cytoplasmic vesicle GO:0031410 IEA     receptor complex GO:0043235 IBA     receptor complex GO:0043235 ISO     perinuclear region of cytoplasm GO:0048471 ISO     postsynapse GO:0098794 IDA     postsynapse GO:0098794 IMP     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP